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Prion Protein (106-126) (trifluoroacetate salt)

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    Prion Protein (106-126) (trifluoro<wbr/>acetate salt)
  • Prion Protein (106-126) (trifluoro<wbr/>acetate salt)
Cat No: 24556
Biochemicals - Small Molecule Activators
Cayman

Prion Protein (106-126) is a peptide fragment of the cellular prion protein PrPc.{41468} It forms fibrils that are organized into β-strands, a behavior characteristic of amyloids. It is toxic to primary rat hippocampal neurons at a concentration of 80...

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This product can only be bought through Cayman Chemical. Please contact us.

Territorial Availability: Available through Bertin Technologies only in France
Synonyms:
  • L-lysyl-L-threonyl-L-asparaginyl-L-methionyl-L-lysyl-L-histidyl-L-methionyl-L-alanylglycyl-L-alanyl-L-alanyl-L-alanyl-L-alanylglycyl-L-alanyl-L-valyl-L-valylglycylglycyl-L-leucyl-glycine, trifluoroacetate salt
Correlated keywords:
  • 148439-49-0 256481-26-2 ERK JNK 1 2 PrP106-126 fragment
Product Overview:
Prion Protein (106-126) is a peptide fragment of the cellular prion protein PrPc.{41468} It forms fibrils that are organized into β-strands, a behavior characteristic of amyloids. It is toxic to primary rat hippocampal neurons at a concentration of 80 μM following incubation for 10 days and induces DNA fragmentation and apoptosis. Prion Protein (106-126) (25 μM) activates ERK1 and 2, p38, and JNK1 and 2 kinases, induces apoptosis, increases NADPH oxidase-dependent production of reactive oxygen species (ROS), and decreases glutathione (GSH) levels in 1C115-HT serotonergic and 1C11NE noradrenergic differentiated neuronal cells.{41469} It forms channels in lipid bilayer membranes that are freely permeable to calcium, sodium, potassium, lithium, rubidium, cesium, and chloride ions at a concentration of 20 μM, and channel formation is significantly enhanced by aging and low pH.{41470} In vivo, intraocular injection of prion protein (106-126) (1 mM) increases the number of terminal deoxynucleotidyltransferase-mediated dUTP nick end labeling (TUNEL) positive nuclei in mice 4 days post injection.{41471}
Size 500 µg
Shipping dry ice
Molecular Formula C80H138N26O24S2 • XCF3COOH
SMILES [H]N[C@@H](CCCCN)C(N[C@]([C@@H](C)O)([H])C(N[C@@H](CC(N)=O)C(N[C@H](C(N[C@@H](CCCCN)C(N[C@H](C(N[C@H](C(N[C@H](C(NCC(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(NCC(N[C@H](C(N[C@@H](C(C)C)C(N[C@@H](C(C)C)C(NCC(NCC(N[C@@H](CC(C)C)C(NCC(O)=O)=O)=O)=O)=O)=O)=O)C)=O)
Molecular Weight 1912,2
Formulation A lyophilized powder
Purity ≥95%
Custom Code 3504.00
UNSPSC code 12352100

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Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.

Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.

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