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Amylin (rat, mouse) (trifluoroacetate salt)

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    Amylin (rat, mouse) (trifluoro<wbr/>acetate salt)
  • Amylin (rat, mouse) (trifluoro<wbr/>acetate salt)
Cat No: 24275
Biochemicals - Peptides
Cayman

Amylin is a 37-residue peptide hormone secreted by pancreatic β-cells that reduces food intake, modifies glycogen synthesis, slows gastric emptying, and increases satiety.{35231,38842,38841,38840} It binds to heteromeric complexes of human calcitonin ...

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: 500 µg

This product can only be bought through Cayman Chemical. Please contact us.

Territorial Availability: Available through Bertin Technologies only in France
Synonyms:
  • L-lysyl-L-cysteinyl-L-asparaginyl-L-threonyl-L-alanyl-L-threonyl-L-cysteinyl-L-alanyl-L-threonyl-L-glutaminyl-L-arginyl-L-leucyl-L-alanyl-L-asparaginyl-L-phenylalanyl-L-leucyl-L-valyl-L-arginyl-L-seryl-L-seryl-L-asparaginyl-L-asparaginyl-L-leucylglycyl-L-prolyl-L-valyl-L-leucyl-L-prolyl-L-prolyl-L-threonyl-L-asparaginyl-L-valylglycyl-L-seryl-L-asparaginyl-L-threonyl-L-tyrosinamide, cyclic (2→7)-disulfide, trifluoroacetate salt
Correlated keywords:
  • 124447-81-0 CTR-2 RAMP3 RAMP1
Product Overview:
Amylin is a 37-residue peptide hormone secreted by pancreatic β-cells that reduces food intake, modifies glycogen synthesis, slows gastric emptying, and increases satiety.{35231,38842,38841,38840} It binds to heteromeric complexes of human calcitonin receptor 2 (CTR2) with receptor activity-modifying protein (RAMP) 1 or 3 (IC50s = 7.86 and 6.35 nM, respectively).{39432} It also binds to mouse α-thyroid-stimulating hormone thyrotroph (α-TSH) cells (IC50 = 10.5 nM) and rat nucleus accumbens membrane preparations (Ki = 0.024 nM).{38840,39432} In vitro, amylin (100 nM) inhibits insulin-induced, but not basal, glycogen synthesis in hepatocytes isolated from fasted rats.{38841} It also inhibits insulin-induced glycogen synthesis ex vivo in isolated soleus muscle from fasted rats.{38840} In vivo, amylin delays gastric emptying in rats (ED50 = 69 pmol) and decreases food intake in fasted mice (ED50 = 110 μg/kg).{38842,38840} Unlike human amylin (Item No. 24274), rat amylin does not form fibrils and is not cytotoxic.{38843}
Size 500 µg
Shipping dry ice
Molecular Formula C167H272N52O53S2 • XCF3COOH
SMILES NC([C@@H](NC([C@@]([C@@H](C)O)([H])NC([C@H](CC(N)=O)NC([C@H](CO)NC(CNC([C@H](C(C)C)NC([C@H](CC(N)=O)NC([C@@]([C@@H](C)O)([H])NC([C@@H]1CCCN1C([C@@H]2CCCN2C([C@H](CC(C)C)NC([C@H](C(C)C)NC([C@@H]3CCCN3C(CNC([C@H](CC(C)C)NC([C@H](CC(N)=O)NC([C@H](CC(N)=O)NC(
Molecular Weight 3920,4
Formulation A lyophilized powder
Purity ≥95%
Custom Code 3504.00
UNSPSC code 12352100

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Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.

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