?-Conotoxin MVIIC (trifluoroacet

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?-Conotoxin MVIIC (trifluoroacetate salt)

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Cat No: 24411

Biochemicals - Ion Channel Modulation

ω-Conotoxin MVIIC is a peptide originally isolated from the marine mollusk C. magus.{41436} It blocks N-type calcium channels on rat superior cervical ganglions (SCGs) and P-type calcium channels on rat Purkinje neurons (Kds = 30 and ~50 nM, respectiv...

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Territorial Availability: Available through Bertin Technologies only in France

Synonyms:

L-cysteinyl-L-lysylglycyl-L-lysylglycyl-L-alanyl-L-prolyl-L-cysteinyl-L-arginyl-L-lysyl-L-threonyl-L-methionyl-L-tyrosyl-L-?-aspartyl-L-cysteinyl-L-cysteinyl-L-serylglycyl-L-seryl-L-cysteinylglycyl-L-arginyl-L-arginylglycyl-L-lysyl-L-cysteinamide, cyclic (1?16),(8?20),(15?26)-tris(disulfide), 2,2,2-trifluoroacetate

Correlated keywords:

150770-65-3 SNX230 1368 protein Conopeptide M VIIC VIIA conus 147794-23-8

Product Overview:
ω-Conotoxin MVIIC is a peptide originally isolated from the marine mollusk C. magus.{41436} It blocks N-type calcium channels on rat superior cervical ganglions (SCGs) and P-type calcium channels on rat Purkinje neurons (Kds = 30 and ~50 nM, respectively, in the presence of 5 mM barium).{41437} It also blocks Q-type channels in rat CA3 neurons. ω-Conotoxin MVIIC binds to rat brain membranes (IC50 = 0.3 nM) and completely blocks calcium uptake by rat brain synaptosomes when used at a concentration of 2.5 μM in the presence of 5 mM potassium.{41436} It blocks potassium-evoked dopamine (Item No. 21992) release from rat striatal slices (IC50 = ~128 nM) and potassium-evoked calcium-dependent glutamate release from rat brain synaptosomes.{41438,41439}

Size	100 µg
Shipping	dry ice
Molecular Formula	C₁₀₆H₁₇₈N₄₀O₃₂S₇ • XCF₃COOH
SMILES	NC([C@@H](N1)CSSC[C@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@]([C@@H](C)O)([H])NC([C@H](CCCCN)NC([C@H](CCCNC(N)=N)NC([C@@H](NC([C@@H]2CCCN2C([C@@H](NC(CNC([C@H](CCCCN)NC(CNC([C@H](CCCCN)NC([C@@H](N[H])CSSC[C@H](N3)C(N[C@@H](CO)C(NCC4=O)=O)=O)=O)=O)=O)=O)=O
Molecular Weight	2749,3
Formulation	A lyophilized powder
Purity	≥95%
Custom Code	3504.00
UNSPSC code	12352100

Technical File

MSDS

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Cayman Chemical's mission is to help make research possible by supplying scientists worldwide with the basic research tools necessary for advancing human and animal health. Our utmost commitment to healthcare researchers is to offer the highest quality products with an affordable pricing policy.

Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.

Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.

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ISO Guide 34:2009

Cayman is a leader in the field of emerging drugs of abuse, providing high-purity Schedule I-V Controlled Substances to federally-licensed laboratories and qualified academic research institutions for forensic analyses. We are certified by ACLASS Accreditation Services with dual accreditation to ISO/IEC 17025:2005 and ISO Guide 34:2009.