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CALP1 (trifluoroacetate salt)

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    CALP1 (trifluoroacetate salt)
  • CALP1 (trifluoroacetate salt)
Cat No: 24402
Biochemicals - Ion Channel Modulation
Cayman

CALP1 is an 8-residue calcium-like peptide that interacts with an EF hand motif based on the troponin C superfamily calcium binding site.{39607} It binds to calmodulin (Kd = 88 µM) and activates phosphodiesterase in the presence of calmodulin and abse...

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Territorial Availability: Available through Bertin Technologies only in France
Synonyms:
  • L-valyl-L-alanyl-L-isoleucyl-L-threonyl-L-valyl-L-leucyl-L-valyl-L-lysine, trifluoroacetate salt
Correlated keywords:
  • 145224-99-3 CALP-1
Product Overview:
CALP1 is an 8-residue calcium-like peptide that interacts with an EF hand motif based on the troponin C superfamily calcium binding site.{39607} It binds to calmodulin (Kd = 88 µM) and activates phosphodiesterase in the presence of calmodulin and absence of calcium. CALP1 also acts as a cell-permeable inhibitor of calcium influx through glutamate receptor channels in cultured rat neocortical neurons thereby inhibiting excitatory cytotoxicity (IC50 = 52.48 µM) and apoptosis (IC50 = 44.78 µM).{39608} CALP1 (1 mg/kg) pretreatment prevents increases in lung alveolar inflammatory cells after six, but not 24, hours in sensitized guinea pigs challenged with ovalbumin in a model of allergic asthma.{39609} It also decreases radical production induced by phorbol 12-myristate 13-acetate (PMA; Item No. 10008014) in broncho-alveolar lavage cells after six and 24 hours and dose-dependently decreases histamine-induced hyperresponsiveness in isolated guinea pig tracheal rings.
Size 1 mg
Shipping dry ice
Molecular Formula C40H75N9O10 • XCF3COOH
SMILES O=C([C@@H](NC([C@@H](NC([C@H](C(C)C)N)=O)C)=O)[C@H](CC)C)N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@@H](CCCCN)C(O)=O)=O)C(C)C)=O)CC(C)C)=O)C(C)C)=O)[C@@H](C)O.FC(F)(C(O)=O)F
Molecular Weight 842,1
Formulation A crystalline solid
Purity ≥95%
Custom Code 3504.00
UNSPSC code 12352100

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Cayman Chemical's mission is to help make research possible by supplying scientists worldwide with the basic research tools necessary for advancing human and animal health. Our utmost commitment to healthcare researchers is to offer the highest quality products with an affordable pricing policy.

Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.

Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.

Our organic and analytical chemists specialize in the rapid development of manufacturing processes and analytical methods to carry out clinical and commercial GMP-API production. Pre-clinical drug discovery efforts are currently underway in the areas of bone restoration and repair, muscular dystrophy, oncology, and inflammation. A separate group of Ph.D.-level scientists are dedicated to offering Hit-to-Lead Discovery and Profiling Services for epigenetic targets. Our knowledgeable chemists can be contracted to perform complete sample analysis for analytes measured by the majority of our assays. We also offer a wide range of analytical services using LC-MS/MS, HPLC, GC, and many other techniques.

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ISO Guide 34:2009

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