Atrial Natriuretic Peptide (1-28

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Atrial Natriuretic Peptide (1-28) (rat) (trifluoroacetate salt)

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Cat No: 24276

Biochemicals - Peptides

Atrial natriuretic peptide (ANP) is an endogenous peptide generated by proteolysis of prepro-ANP that is secreted by cardiomyocytes in the heart.{39427,39428} It has effects on the renal and cardiovascular systems that decrease vasoconstriction, inhib...

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Territorial Availability: Available through Bertin Technologies only in France

Synonyms:

L-seryl-L-leucyl-L-arginyl-L-arginyl-L-seryl-L-seryl-L-cysteinyl-L-phenylalanylglycylglycyl-L-arginyl-L-isoleucyl-L-?-aspartyl-L-arginyl-L-isoleucylglycyl-L-alanyl-L-glutaminyl-L-serylglycyl-L-leucylglycyl-L-cysteinyl-L-asparaginyl-L-seryl-L-phenylalanyl-L-arginyl-L-tyrosine, cyclic (7? 23)-disulfide, trifluoroacetate salt

Correlated keywords:

88898-17-3 preproANP

Product Overview:
Atrial natriuretic peptide (ANP) is an endogenous peptide generated by proteolysis of prepro-ANP that is secreted by cardiomyocytes in the heart.{39427,39428} It has effects on the renal and cardiovascular systems that decrease vasoconstriction, inhibit renin secretion, and increase sodium excretion. In rat kidney cortex ex vivo, exogenous rat ANP inhibits basal renin release in a dose-dependent manner and inhibits renin release induced by isoproterenol (Item No. 15592) with an IC50 value of 58 nM.{39429} ANP (8 µg/kg) decreases plasma renin activity and cAMP levels in anesthetized rats and increases cGMP levels. It also inhibits arginine vasopressin-induced increases in mean arterial blood pressure in spontaneously hypertensive and control rats when administered intracerebroventricularly at a dose of 150 ng.{39430} ANP (1-28) (rat) is a 28 amino acid peptide corresponding to the rat protein sequence.

Size	250 µg
Shipping	dry ice
Molecular Formula	C₁₂₈H₂₀₅N₄₅O₃₉S₂ • XCF₃COOH
SMILES	[H]N[C@@H](CO)C(N[C@@H](CC(C)C)C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CO)C(N[C@@H](CO)C(N[C@H](C(N[C@H](C(NCC(NCC(N[C@@H](CCCNC(N)=N)C(N[C@]([C@H](CC)C)([H])C(N[C@H](C(N[C@@H](CCCNC(N)=N)C(N[C@]([C@H](CC)C)([H])C(NCC(N[C@H](C(N[C@@H](CCC(N)=O
Molecular Weight	3062,4
Formulation	A lyophilized powder
Purity	≥95%
Custom Code	3504.00
UNSPSC code	12352100

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Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.

Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.

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ISO/IEC 17025:2005
ISO Guide 34:2009

Cayman is a leader in the field of emerging drugs of abuse, providing high-purity Schedule I-V Controlled Substances to federally-licensed laboratories and qualified academic research institutions for forensic analyses. We are certified by ACLASS Accreditation Services with dual accreditation to ISO/IEC 17025:2005 and ISO Guide 34:2009.