(±)-Muscarine (hydrate)

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Cat No: 24269

Biochemicals - Natural Products

(±)-Muscarine is an agonist of muscarinic acetylcholine receptors that was originally found in A. muscaria.{36535} It induces spasms in isolated intestinal ileum from mouse, guinea pig, rabbit, dog, monkey, and horse, contraction of longitudinal uteri...

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Territorial Availability: Available through Bertin Technologies only in France

Synonyms:

2,5-anhydro-1,3,6-trideoxy-1-(trimethylammonio)-ribo-hexitol, monochloride, hydrate

Correlated keywords:

71-06-7 300-54-9 4293-78-1 2303-35-7 anti-nociceptive Amanita DL muscarin 2936-25-6

Product Overview:
(±)-Muscarine is an agonist of muscarinic acetylcholine receptors that was originally found in A. muscaria.{36535} It induces spasms in isolated intestinal ileum from mouse, guinea pig, rabbit, dog, monkey, and horse, contraction of longitudinal uterine and bladder muscle strips from mouse, guinea pig, rabbit, rat, horse, and dog, and slows the heart rate of isolated guinea pig and rabbit atria. In vivo, (±)-muscarine induces bronchoconstriction in guinea pigs and rabbits as well as respiratory depression in rabbits and cats with minimum active doses (MADs) ranging from 1 to 5 μg/kg. It reduces blood pressure in cats, dogs, and rabbits and induces uterine, bladder, and intestinal contraction in cats and dogs. (±)-Muscarine (0.005-0.01 mg/kg) increases circling and pacing behaviors and induces fear aggression in cats.{36536} It has antinociceptive activity in rats in the hot plate and tail-flick tests.{36537} (±)-Muscarine also inhibits acetylcholinesterase (Ki = 220 μM).{36538}

Size	1 mg
Shipping	dry ice
CAS Number	2241280-55-5
Molecular Formula	C₉H₂₀NO₂ • Cl [XH₂O]
SMILES	C[C@@H]1[C@@H](O)C[C@H](C[N+](C)(C)C)O1.[Cl-].O
Molecular Weight	174,3
Formulation	A crystalline solid
Purity	≥95%
Custom Code	2932.19
UNSPSC code	12352100

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Cayman Chemical's mission is to help make research possible by supplying scientists worldwide with the basic research tools necessary for advancing human and animal health. Our utmost commitment to healthcare researchers is to offer the highest quality products with an affordable pricing policy.

Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.

Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.

Our organic and analytical chemists specialize in the rapid development of manufacturing processes and analytical methods to carry out clinical and commercial GMP-API production. Pre-clinical drug discovery efforts are currently underway in the areas of bone restoration and repair, muscular dystrophy, oncology, and inflammation. A separate group of Ph.D.-level scientists are dedicated to offering Hit-to-Lead Discovery and Profiling Services for epigenetic targets. Our knowledgeable chemists can be contracted to perform complete sample analysis for analytes measured by the majority of our assays. We also offer a wide range of analytical services using LC-MS/MS, HPLC, GC, and many other techniques.

Accreditations
ISO/IEC 17025:2005
ISO Guide 34:2009

Cayman is a leader in the field of emerging drugs of abuse, providing high-purity Schedule I-V Controlled Substances to federally-licensed laboratories and qualified academic research institutions for forensic analyses. We are certified by ACLASS Accreditation Services with dual accreditation to ISO/IEC 17025:2005 and ISO Guide 34:2009.