Laquinimod

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Laquinimod

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Cat No: 24187

Biochemicals - More Biochemicals

Laquinimod is an orally bioavailable immunomodulator.{40911} It induces expression of genes related to antigen presentation and inflammatory pathways in human peripheral blood mononuclear cells (PBMCs) when used at a concentration of 0.1 μM.{40912} In...

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Territorial Availability: Available through Bertin Technologies only in France

Synonyms:

5-chloro-N-ethyl-1,2-dihydro-4-hydroxy-1-methyl-2-oxo-N-phenyl-3-quinolinecarboxamide

Correlated keywords:

LAQ ABR215062 TV 5600

Product Overview:
Laquinimod is an orally bioavailable immunomodulator.{40911} It induces expression of genes related to antigen presentation and inflammatory pathways in human peripheral blood mononuclear cells (PBMCs) when used at a concentration of 0.1 μM.{40912} In a mouse model of acute autoimmune encephalomyelitis (aEAE), laquinimod (5 mg/kg per day) decreases the severity of symptoms by 91.4%, and it decreases the number of relapses in a mouse model of chronic EAE (crEAE).{40911} It decreases T cell and macrophage density and demyelination in the spinal cord of EAE mice compared to non-treated controls when administered at a dose of 5 mg/kg per day.{40913} Laquinimod (12.5 and 25 mg/kg per day) decreases inflammatory lesions and demyelination in the sciatic nerve in a rat model of experimental autoimmune neuritis (EAN).{40914} Laquinimod (25 mg/kg per day) activates gene expression in the aryl hydrocarbon receptor (AhR) pathway in splenocytes from EAE mice with no effect in AhR knockout mice.{40915}

Size	100 mg
Shipping	dry ice
CAS Number	248281-84-7
Molecular Formula	C₁₉H₁₇ClN₂O₃
SMILES	ClC1=C(C(O)=C(C(N(CC)C2=CC=CC=C2)=O)C(N3C)=O)C3=CC=C1
Molecular Weight	356,8
Formulation	A crystalline solid
Purity	≥98%
Custom Code	2903.99
UNSPSC code	12352100

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Cayman Chemical's mission is to help make research possible by supplying scientists worldwide with the basic research tools necessary for advancing human and animal health. Our utmost commitment to healthcare researchers is to offer the highest quality products with an affordable pricing policy.

Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.

Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.

Our organic and analytical chemists specialize in the rapid development of manufacturing processes and analytical methods to carry out clinical and commercial GMP-API production. Pre-clinical drug discovery efforts are currently underway in the areas of bone restoration and repair, muscular dystrophy, oncology, and inflammation. A separate group of Ph.D.-level scientists are dedicated to offering Hit-to-Lead Discovery and Profiling Services for epigenetic targets. Our knowledgeable chemists can be contracted to perform complete sample analysis for analytes measured by the majority of our assays. We also offer a wide range of analytical services using LC-MS/MS, HPLC, GC, and many other techniques.

Accreditations
ISO/IEC 17025:2005
ISO Guide 34:2009

Cayman is a leader in the field of emerging drugs of abuse, providing high-purity Schedule I-V Controlled Substances to federally-licensed laboratories and qualified academic research institutions for forensic analyses. We are certified by ACLASS Accreditation Services with dual accreditation to ISO/IEC 17025:2005 and ISO Guide 34:2009.