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18?-Glycyrrhetinic Acid

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    18?-<wbr/>Glycyrrhetinic Acid
  • 18?-<wbr/>Glycyrrhetinic Acid
Cat No: 11845
Biochemicals - Natural Products
Cayman

18β-Glycyrrhetinic acid is a major metabolite of glycyrrhizin (Item No. 11847), one of the main constituents of licorice. Both 18β-glycyrrhetinic acid and glycyrrhizin have been shown to exhibit anti-ulcerative, anti-inflammatory, and immunomodulatory...

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Territorial Availability: Available through Bertin Technologies only in France
Synonyms:
  • (20?)-3?-hydroxy-11-oxo-olean-12-en-29-oic acid
Correlated keywords:
  • 8055-71-8 15301-63-0 107420-91-7 202522-39-2 299198-00-8 GM1658 GM-1658 glycyrrhetic glycyrrhetin NSC35347 NSC-35347 PO12 PO-12 STX-352 STX352 subglycyrrhelinic ?-glycyrrhetinic metabolites glycyrrhizin licorice anti-ulcer antiulcer ulcers anti anti-inflammatory inflammatory anti-inflammatory immunomodulator immunomodulatory inhibitors inhibits inhibition complement pathways diabetes lipids peroxidation antioxidant polymerase TNF-? NF?B TNF? TNF-alpha TNF-.alpha. TNFalpha TNF.alpha. TNFa TNF-a NF-kB NFkB NF-.kappa.B NF-kappaB NFkappaB NF.kappaB NF-?B
Product Overview:
18β-Glycyrrhetinic acid is a major metabolite of glycyrrhizin (Item No. 11847), one of the main constituents of licorice. Both 18β-glycyrrhetinic acid and glycyrrhizin have been shown to exhibit anti-ulcerative, anti-inflammatory, and immunomodulatory properties. 18β-Glycyrrhetinic acid is an inhibitor of the complement pathway (IC50 = 35 μM).{21413} At 100 mg/kg/day, 18β-glycyrrhetinic acid is protective against diabetes complications by reducing lipid peroxidation and increasing antioxidant activity in diabetic rats.{21415} 18β-Glycyrrhetinic acid inhibits mammalian DNA polymerases α, γ, κ, and λ with IC50 values of 16.1, 19.3, 15.8, and 13.7 μM, respectively.{21414} At 100-200 μM, 18β-glycyrrhetinic acid suppresses LPS-induced TNF-α production and NF-κB activation in mouse macrophages.{21414}
Size 1 g
Shipping dry ice
CAS Number 471-53-4
Molecular Formula C30H46O4
SMILES CC1(C)[C@@H](O)CC[C@@]2(C)[C@@]1([H])CC[C@]([C@@](CC[C@]3(C)[C@@]4([H])C[C@@](C)(C(O)=O)CC3)(C)C4=C5)(C)[C@]2([H])C5=O
Molecular Weight 470,7
Formulation A crystalline solid
Purity ≥98%
Custom Code 2907.19
UNSPSC code 12352100

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Cayman Chemical's mission is to help make research possible by supplying scientists worldwide with the basic research tools necessary for advancing human and animal health. Our utmost commitment to healthcare researchers is to offer the highest quality products with an affordable pricing policy.

Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.

Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.

Our organic and analytical chemists specialize in the rapid development of manufacturing processes and analytical methods to carry out clinical and commercial GMP-API production. Pre-clinical drug discovery efforts are currently underway in the areas of bone restoration and repair, muscular dystrophy, oncology, and inflammation. A separate group of Ph.D.-level scientists are dedicated to offering Hit-to-Lead Discovery and Profiling Services for epigenetic targets. Our knowledgeable chemists can be contracted to perform complete sample analysis for analytes measured by the majority of our assays. We also offer a wide range of analytical services using LC-MS/MS, HPLC, GC, and many other techniques.

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