Vaborbactam

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Vaborbactam

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Cat No: 23962

Biochemicals - Anti-Infection

Vaborbactam is an inhibitor of β-lactamases (Kis = 29-110 nM for class A and class C enzymes).{36683} It is selective for bacterial β-lactamases over a panel of mammalian serine proteases (IC50s = ≥1,000 μM). Vaborbactam potentiates the activity of bi...

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Territorial Availability: Available through Bertin Technologies only in France

Synonyms:

2-hydroxy-3R-[[2-(2-thienyl)acetyl]amino]-1,2-oxaborinane-6S-acetic acid

Correlated keywords:

1575712-03-6 Klebsiella KPC2 anti-biotic Escherichia Enterobacter RPX7009

Product Overview:
Vaborbactam is an inhibitor of β-lactamases (Kis = 29-110 nM for class A and class C enzymes).{36683} It is selective for bacterial β-lactamases over a panel of mammalian serine proteases (IC50s = ≥1,000 μM). Vaborbactam potentiates the activity of biapenem against K. pneumonia expressing the β-lactamase KPC-2, reducing the MIC value for biapenem from 32 to 1 μg/ml when used at a concentration of 0.02 μg/ml. It also potentiates the activity of the carbapenem antibiotics biapenem, meropenem (Item No. 16068), ertapenem, and imipenem (Item No. 16039) against clinical isolates of E. coli, E. cloacae, K. oxytoca, and K. pneumoniae that produce serine β-lactamases (MICs = ≤0.06-4 and 4-64 μg/ml in the presence and absence of vaborbactam, respectively). In vivo, vaborbactam (50 mg/kg) reduces the number of colony forming units (CFUs) in the lung in a neutropenic mouse lung infection model when used in combination with biapenem or meropenem. Formulations containing vaborbactam in combination with meropenem have been used for the treatment of carbapenem-resistant Enterobacteriaceae infections.

Size	1 mg
Shipping	dry ice
CAS Number	1360457-46-0
Molecular Formula	C₁₂H₁₆BNO₅S
SMILES	OB1O[C@H](CC(O)=O)CC[C@@H]1NC(CC2=CC=CS2)=O
Molecular Weight	297,1
Formulation	A crystalline solid
Purity	≥95%
Custom Code	2930.90
UNSPSC code	12352100

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Cayman Chemical's mission is to help make research possible by supplying scientists worldwide with the basic research tools necessary for advancing human and animal health. Our utmost commitment to healthcare researchers is to offer the highest quality products with an affordable pricing policy.

Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.

Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.

Our organic and analytical chemists specialize in the rapid development of manufacturing processes and analytical methods to carry out clinical and commercial GMP-API production. Pre-clinical drug discovery efforts are currently underway in the areas of bone restoration and repair, muscular dystrophy, oncology, and inflammation. A separate group of Ph.D.-level scientists are dedicated to offering Hit-to-Lead Discovery and Profiling Services for epigenetic targets. Our knowledgeable chemists can be contracted to perform complete sample analysis for analytes measured by the majority of our assays. We also offer a wide range of analytical services using LC-MS/MS, HPLC, GC, and many other techniques.

Accreditations
ISO/IEC 17025:2005
ISO Guide 34:2009

Cayman is a leader in the field of emerging drugs of abuse, providing high-purity Schedule I-V Controlled Substances to federally-licensed laboratories and qualified academic research institutions for forensic analyses. We are certified by ACLASS Accreditation Services with dual accreditation to ISO/IEC 17025:2005 and ISO Guide 34:2009.