Dihydroergotamine (mesylate)

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Cat No: 23847

Biochemicals - Receptor Pharmacology

Dihydroergotamine is a derivative of ergotamine and an agonist of the serotonin (5-HT) receptor subtypes 5-HT1B and 5-HT1D (Kis = 0.3 and 2.5 nM, respectively, for human receptors).{41322} It binds to dopamine D2 and D3 as well as 5-HT2A receptors (K0...

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Territorial Availability: Available through Bertin Technologies only in France

Synonyms:

(5'?,10?)-9,10-dihydro-12'-hydroxy-2'-methyl-5'-(phenylmethyl)-ergotaman-3',6',18-trione, methanesulfonate

Correlated keywords:

511-12-6 37-48-9 1381-02-8 5707-14-2 11041-28-4 56532-69-5 122074-71-9 885319-97-1 Agit Angionorm DETMS DHE 45 DHE45 Dergotamine Diergo Dihydergot Dihytamine Dirgotarl Endophleban Ergomimet Ergont Ergotonin Ikaran Migranal Morena Orstanorm Seglor Tonopres Verladyn 5HT dihydro

Product Overview:
Dihydroergotamine is a derivative of ergotamine and an agonist of the serotonin (5-HT) receptor subtypes 5-HT1B and 5-HT1D (Kis = 0.3 and 2.5 nM, respectively, for human receptors).{41322} It binds to dopamine D2 and D3 as well as 5-HT2A receptors (K0.5s = 5, 16, and 38 nM, respectively) but has lower affinity for D1, 5-HT2C, and 5-HT3 receptors (K0.5s = 2,779, 298, and >10,000 nM, respectively).{41323} Dihydroergotamine also binds to α-adrenergic receptors.{41324} Dihydroergotamine (50 and 100 mg/kg) increases the mechanical pain threshold in a rat model of neuropathic pain following chronic constriction injury to the infraorbital nerve. Formulations containing dihydroergotamine have been used in the treatment of migraine headaches.{41321}

Size	25 mg
Shipping	dry ice
CAS Number	6190-39-2
Molecular Formula	C₃₃H₃₇N₅O₅ • CH₃SO₃H
SMILES	CN1[C@]([C@]2([H])C[C@@H](C(N[C@@]3(C)C(N([C@@H](CC4=CC=CC=C4)C(N5[C@@]6([H])CCC5)=O)[C@@]6(O)O3)=O)=O)C1)([H])CC7=CNC8=C7C2=CC=C8.OS(=O)(C)=O
Molecular Weight	679,8
Formulation	A crystalline solid
Purity	≥98%
Custom Code	2924.19
UNSPSC code	12352100

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Cayman Chemical's mission is to help make research possible by supplying scientists worldwide with the basic research tools necessary for advancing human and animal health. Our utmost commitment to healthcare researchers is to offer the highest quality products with an affordable pricing policy.

Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.

Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.

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