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Piroxicam

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    Piroxicam
  • Piroxicam
Cat No: 13368
Biochemicals - Small Molecule Inhibitors
Cayman

Piroxicam is a COX inhibitor and non-steroidal anti-inflammatory drug (NSAID) with anti-inflammatory and analgesic properties.{17755,7909} It inhibits production of thromboxane B2 (TXB2; Item No. 19030) from arachidonic acid (Item Nos. 90010
90010.1...

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Territorial Availability: Available through Bertin Technologies only in France
Synonyms:
  • 4-hydroxy-2-methyl-N-2-pyridinyl-2H-1,2-benzothiazine-3-carboxamide-1,1-dioxide
Correlated keywords:
  • antiinflammation NSAIDs cyclooxygenases COX1 COX2 analgesic pain arthritis cancers Artrooxicam Baxo Bruxicam CP 16171 Geldene Neoxicam Reudene Roxicam Roxiden Sasulen Solocalm Uphaxicam Zunden inhibition inhibited inflammatory Piroxicam CP-16171 CP16171 Feldene Larapam CP16171 NSC666076 NO interleukin RA TXB IL6
Product Overview:
Piroxicam is a COX inhibitor and non-steroidal anti-inflammatory drug (NSAID) with anti-inflammatory and analgesic properties.{17755,7909} It inhibits production of thromboxane B2 (TXB2; Item No. 19030) from arachidonic acid (Item Nos. 90010
90010.1
10006607) in HEL human erythroleukemic cells (IC50 = 0.45 µM), which endogenously express COX-1, as well as inhibits LPS-induced formation of prostaglandin F1α (PGF1α; Item No. 15010) from arachidonic acid in Mono-Mac-6 cells (IC50 = 0.77 µM), which endogenously express COX-2.{7909} Lornoxicam reduces LPS-induced production of nitric oxide and IL-6 in cell-based assays with IC50 values of 240 and ~470 µM, respectively. It reduces carrageenan-induced paw edema in rats when administered at doses of 1, 2.5, and 5 mg/kg.{58296} Formulations containing piroxicam have been used in the treatment of pain and inflammation associated with osteoarthritis and rheumatoid arthritis.
Size 500 mg
Shipping dry ice
CAS Number 36322-90-4
Molecular Formula C15H13N3O4S
SMILES O=C(C(N1C)=C(O)C2=CC=CC=C2S1(=O)=O)NC3=CC=CC=N3
Molecular Weight 331,4
Formulation A crystalline solid
Purity ≥95%
Custom Code 2917.39
UNSPSC code 12352100

Pairet, M., van Ryn, J., Schierok, H., et al. Differential inhibition of cyclooxygenases-1 and -2 by meloxicam and its 4'-isomer. Inflamm Res 47 270-276 (1998).

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Cayman Chemical's mission is to help make research possible by supplying scientists worldwide with the basic research tools necessary for advancing human and animal health. Our utmost commitment to healthcare researchers is to offer the highest quality products with an affordable pricing policy.

Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.

Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.

Our organic and analytical chemists specialize in the rapid development of manufacturing processes and analytical methods to carry out clinical and commercial GMP-API production. Pre-clinical drug discovery efforts are currently underway in the areas of bone restoration and repair, muscular dystrophy, oncology, and inflammation. A separate group of Ph.D.-level scientists are dedicated to offering Hit-to-Lead Discovery and Profiling Services for epigenetic targets. Our knowledgeable chemists can be contracted to perform complete sample analysis for analytes measured by the majority of our assays. We also offer a wide range of analytical services using LC-MS/MS, HPLC, GC, and many other techniques.

Accreditations
ISO/IEC 17025:2005
ISO Guide 34:2009

Cayman is a leader in the field of emerging drugs of abuse, providing high-purity Schedule I-V Controlled Substances to federally-licensed laboratories and qualified academic research institutions for forensic analyses. We are certified by ACLASS Accreditation Services with dual accreditation to ISO/IEC 17025:2005 and ISO Guide 34:2009.

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