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Piroxicam

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    Piroxicam
  • Piroxicam
Cat No: 13368
Biochemicals - Small Molecule Inhibitors
Cayman
€20.00
Price is excluding VAT and does not include packaging neither shipping

Piroxicam is a non-steroidal anti-inflammatory drug (NSAID) that non-selectively and reversibly inhibits both isoforms of cyclooxygenase (COX; IC50 = 1.57 and 1.69 μM for COX-1 and COX-2, respectively).{17755} It has an extended half-life of about 40 ...

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This product can only be bought through Cayman Chemical. Please contact us.

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Territorial Availability: Available through Bertin Technologies only in Europe
Synonyms:
  • 4-hydroxy-2-methyl-N-2-pyridinyl-2H-1,2-benzothiazine-3-carboxamide-1,1-dioxide
Correlated keywords:
  • inflammation NSAIDs inhibitors cyclooxygenases COX-1 COX-2 analgesic pain arthritis cancers Artrooxicam Baxo Bruxicam CP 16171 Geldene Neoxicam Reudene Roxicam Roxiden Sasulen Solocalm Uphaxicam Zunden inhibition inhibited inflammatory Piroxicam CP-16171 CP 16171 Feldene CP16171
Product Overview:
Piroxicam is a non-steroidal anti-inflammatory drug (NSAID) that non-selectively and reversibly inhibits both isoforms of cyclooxygenase (COX; IC50 = 1.57 and 1.69 μM for COX-1 and COX-2, respectively).{17755} It has an extended half-life of about 40 hours, which allows once daily administration leading to sustained plasma and tissue levels. In addition to its anti-inflammatory effects, piroxicam is known to be an effective analgesic that has been used extensively in the treatment of arthritis. It has also been used to inhibit COX activity for treatment of certain cancers in animals. As with other NSAIDs, the extended use of piroxicam results in damage to the gastrointestinal lining.
Size 500 mg
Shipping dry ice
Stability Store at -20 degrees; shelf life 730 days
CAS Number 36322-90-4
Molecular Formula C15H13N3O4S
SMILES O=C(C(N1C)=C(O)C2=CC=CC=C2S1(=O)=O)NC3=CC=CC=N3
Molecular Weight 331,4
Formulation A crystalline solid
Purity ≥95%
Custom Code 2917.39
UNSPSC code 12352100

Pairet, M., van Ryn, J., Schierok, H., et al. Differential inhibition of cyclooxygenases-1 and -2 by meloxicam and its 4'-isomer. Inflamm Res 47 270-276 (1998).

Cayman Chemical's mission is to help make research possible by supplying scientists worldwide with the basic research tools necessary for advancing human and animal health. Our utmost commitment to healthcare researchers is to offer the highest quality products with an affordable pricing policy.

Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.

Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.

Our organic and analytical chemists specialize in the rapid development of manufacturing processes and analytical methods to carry out clinical and commercial GMP-API production. Pre-clinical drug discovery efforts are currently underway in the areas of bone restoration and repair, muscular dystrophy, oncology, and inflammation. A separate group of Ph.D.-level scientists are dedicated to offering Hit-to-Lead Discovery and Profiling Services for epigenetic targets. Our knowledgeable chemists can be contracted to perform complete sample analysis for analytes measured by the majority of our assays. We also offer a wide range of analytical services using LC-MS/MS, HPLC, GC, and many other techniques.

Accreditations
ISO/IEC 17025:2005
ISO Guide 34:2009

Cayman is a leader in the field of emerging drugs of abuse, providing high-purity Schedule I-V Controlled Substances to federally-licensed laboratories and qualified academic research institutions for forensic analyses. We are certified by ACLASS Accreditation Services with dual accreditation to ISO/IEC 17025:2005 and ISO Guide 34:2009.

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