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  • Piroxicam
Cat No: 13368
Biochemicals - Small Molecule Inhibitors

Piroxicam is a COX inhibitor and non-steroidal anti-inflammatory drug (NSAID) with anti-inflammatory and analgesic properties.{17755,7909} It inhibits production of thromboxane B2 (TXB2; Item No. 19030) from arachidonic acid (Item Nos. 90010


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Territorial Availability: Available through Bertin Technologies only in France
  • 4-hydroxy-2-methyl-N-2-pyridinyl-2H-1,2-benzothiazine-3-carboxamide-1,1-dioxide
Correlated keywords:
  • antiinflammation NSAIDs cyclooxygenases COX1 COX2 analgesic pain arthritis cancers Artrooxicam Baxo Bruxicam CP 16171 Geldene Neoxicam Reudene Roxicam Roxiden Sasulen Solocalm Uphaxicam Zunden inhibition inhibited inflammatory Piroxicam CP-16171 CP16171 Feldene Larapam CP16171 NSC666076 NO interleukin RA TXB IL6
Product Overview:
Piroxicam is a COX inhibitor and non-steroidal anti-inflammatory drug (NSAID) with anti-inflammatory and analgesic properties.{17755,7909} It inhibits production of thromboxane B2 (TXB2; Item No. 19030) from arachidonic acid (Item Nos. 90010
10006607) in HEL human erythroleukemic cells (IC50 = 0.45 µM), which endogenously express COX-1, as well as inhibits LPS-induced formation of prostaglandin F1α (PGF1α; Item No. 15010) from arachidonic acid in Mono-Mac-6 cells (IC50 = 0.77 µM), which endogenously express COX-2.{7909} Lornoxicam reduces LPS-induced production of nitric oxide and IL-6 in cell-based assays with IC50 values of 240 and ~470 µM, respectively. It reduces carrageenan-induced paw edema in rats when administered at doses of 1, 2.5, and 5 mg/kg.{58296} Formulations containing piroxicam have been used in the treatment of pain and inflammation associated with osteoarthritis and rheumatoid arthritis.
Size 500 mg
Shipping dry ice
CAS Number 36322-90-4
Molecular Formula C15H13N3O4S
Molecular Weight 331,4
Formulation A crystalline solid
Purity ≥95%
Custom Code 2917.39
UNSPSC code 12352100

Pairet, M., van Ryn, J., Schierok, H., et al. Differential inhibition of cyclooxygenases-1 and -2 by meloxicam and its 4'-isomer. Inflamm Res 47 270-276 (1998).

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Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.

Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.

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