Famotidine

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Famotidine

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Cat No: 23828

Biochemicals - Receptor Pharmacology

Famotidine is a histamine H2 receptor antagonist with a Ki value of 12 nM in fractionated guinea pig cerebral cortex membranes.{36463} It is selective for H2 over H1 and muscarinic receptors (Kis = 4 and 28 µM, respectively, in bovine cerebral cortex)...

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Territorial Availability: Available through Bertin Technologies only in France

Synonyms:

3-[[[2-[(aminoiminomethyl)amino]-4-thiazolyl]methyl]thio]-N-(aminosulfonyl)-propanimidamide

Correlated keywords:

214692-67-8 YM11170 H-2 1 antiinflammatory Agufam Amfamox Antodine Apo Apogastine Bestidine Brolin Cepal Dibrit 40 Digervin Dispromil Dispronil Durater Facid Fadin Fadine Fadyn Fagastine FamoABZ Famocid Famodar Famodil Famodin Famodine Famogard Famogast Famolta Famonerton Famopsin Famos Famosan Famoser Famostagine-D Famotal Famotep Famotin Famotine Famowal Famox Famoxal Fanosin Fanox Farmotex Fenox Fibonel Fudone Fuweidin Ganor mite Gaster Gastridin Gastrion Gastro Gastrodomina Gastropen H 2 Bloc Ifada Kemofam Lecedil Logos MK 208 MK208 Mabo Mosul Motiax Muclox Nevofam Nulcerin Panalba Pepcid AC PM Pepcidin Pepcidin Rapitab Pepcidina Pepcidine Pepdif Pepdine Pepfamin Peptan Peptec Peptifam Pepzan Purifam Quamatel Quamtel Restadin Rogasti Sedanium R Servipep Supertidine Tamin Topcid Ulcatif Ulcedine Ulceran Ulcetrax Ulcidine Ulcofam Ulfagel Ulfam Ulfamid Ulfinol Ulped AR Weimok nonsteroidal famo pepdul

Product Overview:
Famotidine is a histamine H2 receptor antagonist with a Ki value of 12 nM in fractionated guinea pig cerebral cortex membranes.{36463} It is selective for H2 over H1 and muscarinic receptors (Kis = 4 and 28 µM, respectively, in bovine cerebral cortex).{23214} Famotidine inhibits histamine-induced acid secretion in isolated canine parietal cells (IC50 = 0.6 µM).{17620} It also suppresses histamine-induced gastric acid secretion in dogs when administered orally and in anesthetized rats when administered intraduodenally (ID50s = 10 and 400 µg/kg, respectively).{17620} Formulations containing famotidine have been used in the treatment of ulcers, gastroesophageal reflux disease (GERD), and heartburn, as well as to decrease the risk of gastrointestinal toxicity associated with non-steroidal anti-inflammatory drugs (NSAIDs).

Size	1 g
Shipping	dry ice
CAS Number	76824-35-6
Molecular Formula	C₈H₁₅N₇O₂S₃
SMILES	NS(NC(CCSCC1=CSC(NC(N)=N)=N1)=N)(=O)=O
Molecular Weight	337,5
Formulation	A crystalline solid
Purity	≥98%
Custom Code	2935.90
UNSPSC code	12352100

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Cayman Chemical's mission is to help make research possible by supplying scientists worldwide with the basic research tools necessary for advancing human and animal health. Our utmost commitment to healthcare researchers is to offer the highest quality products with an affordable pricing policy.

Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.

Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.

Our organic and analytical chemists specialize in the rapid development of manufacturing processes and analytical methods to carry out clinical and commercial GMP-API production. Pre-clinical drug discovery efforts are currently underway in the areas of bone restoration and repair, muscular dystrophy, oncology, and inflammation. A separate group of Ph.D.-level scientists are dedicated to offering Hit-to-Lead Discovery and Profiling Services for epigenetic targets. Our knowledgeable chemists can be contracted to perform complete sample analysis for analytes measured by the majority of our assays. We also offer a wide range of analytical services using LC-MS/MS, HPLC, GC, and many other techniques.

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Cayman is a leader in the field of emerging drugs of abuse, providing high-purity Schedule I-V Controlled Substances to federally-licensed laboratories and qualified academic research institutions for forensic analyses. We are certified by ACLASS Accreditation Services with dual accreditation to ISO/IEC 17025:2005 and ISO Guide 34:2009.