Naratriptan (hydrochloride)

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Cat No: 23754

Biochemicals - Receptor Pharmacology

Naratriptan is a potent agonist of the serotonin (5-HT) receptor subtypes 5-HT1B and 5-HT1D (IC50s = 9.4 and 1.5 nM, respectively, in a radioligand binding assay using human recombinant receptors).{38513} It is selective for 5-HT1B and 5-HT1D, lacking...

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Territorial Availability: Available through Bertin Technologies only in France

Synonyms:

N-methyl-3-(1-methyl-4-piperidinyl)-1H-indole-5-ethanesulfonamide, monohydrochloride

Correlated keywords:

121679-13-8 Amerge GR85548A Naramig Naratrex-1 5HT-2A 4 7 1D 1B GR-85548A 5HT2A 5HT4 5HT7 5HT1D 5HT1B

Product Overview:
Naratriptan is a potent agonist of the serotonin (5-HT) receptor subtypes 5-HT1B and 5-HT1D (IC50s = 9.4 and 1.5 nM, respectively, in a radioligand binding assay using human recombinant receptors).{38513} It is selective for 5-HT1B and 5-HT1D, lacking activity in rat aorta, guinea pig colon, and pig vena cava, that highly express 5-HT2A, 5-HT4, and 5-HT7 receptors, respectively, at concentrations up to 10 μM.{38514} Naratriptan induces contraction of isolated human coronary arteries (EC50 = 170 nM). In vivo, naratriptan (1-300 μg/kg) induces dose-dependent vasoconstriction of the carotid vascular bed in dogs. It also inhibits plasma protein extravasation induced by electrical stimulation of the trigeminal ganglion in the dura of anesthetized rats. Formulations containing naratriptan have been used in the treatment of migraine headaches.

Size	5 mg
Shipping	dry ice
CAS Number	143388-64-1
Molecular Formula	C₁₇H₂₅N₃O₂S • HCl
SMILES	O=S(CCC1=CC=C2C(C(C3CCN(C)CC3)=CN2)=C1)(NC)=O.Cl
Molecular Weight	371,9
Formulation	A solid
Purity	≥95%
Custom Code	2935.90
UNSPSC code	12352100

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Cayman Chemical's mission is to help make research possible by supplying scientists worldwide with the basic research tools necessary for advancing human and animal health. Our utmost commitment to healthcare researchers is to offer the highest quality products with an affordable pricing policy.

Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.

Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.

Our organic and analytical chemists specialize in the rapid development of manufacturing processes and analytical methods to carry out clinical and commercial GMP-API production. Pre-clinical drug discovery efforts are currently underway in the areas of bone restoration and repair, muscular dystrophy, oncology, and inflammation. A separate group of Ph.D.-level scientists are dedicated to offering Hit-to-Lead Discovery and Profiling Services for epigenetic targets. Our knowledgeable chemists can be contracted to perform complete sample analysis for analytes measured by the majority of our assays. We also offer a wide range of analytical services using LC-MS/MS, HPLC, GC, and many other techniques.

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ISO/IEC 17025:2005
ISO Guide 34:2009

Cayman is a leader in the field of emerging drugs of abuse, providing high-purity Schedule I-V Controlled Substances to federally-licensed laboratories and qualified academic research institutions for forensic analyses. We are certified by ACLASS Accreditation Services with dual accreditation to ISO/IEC 17025:2005 and ISO Guide 34:2009.