Sumatriptan (succinate)

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Cat No: 14600

Biochemicals - Receptor Pharmacology

Sumatriptan is an agonist of the serotonin (5-HT) receptor subtypes 5-HT1B and 5-HT1D (IC50s = 9.3 and 7.3 nM, respectively).{23129} It also binds to the 5-HT1F receptor (IC50 = 17.8 nM). It induces vasoconstriction in isolated human middle meningeal ...

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Territorial Availability: Available through Bertin Technologies only in France

Synonyms:

3-[2-(dimethylamino)ethyl]-N-methyl-1H-indole-5-methanesulfonamide-butanedioic acid

Correlated keywords:

103628-46-2 GR43175 serotonin receptors 5-HT1B 5-HT1D 5-HT1F migraines inflammation vasoconstriction agonists neurosciences humans middle meningeal arteries 5HTs HTs 1B 1D imigrane imiject megrelan migragesin sumagraine sumitrex treximet selective affinity 5HT1B 5-HT1B 5HT1D 5-HT1D 5-HT1F 5HT1F induces reduces vascular 5-hydroxytryptamine imitrex imigran

Product Overview:
Sumatriptan is an agonist of the serotonin (5-HT) receptor subtypes 5-HT1B and 5-HT1D (IC50s = 9.3 and 7.3 nM, respectively).{23129} It also binds to the 5-HT1F receptor (IC50 = 17.8 nM). It induces vasoconstriction in isolated human middle meningeal arteries (EC50 = 89.9 nM), an effect that can be reduced by the 5-HT1B/1D receptor antagonists GR125,743 and GR127,935. Sumatriptan reduces acute, but not chronic, mechanical hyperalgesia in a mouse model of pain induced by nitroglycerin, which is a known migraine trigger in humans.{48340} Formulations containing sumatriptan have been used in the treatment of migraine headache.

Size	5 mg
Shipping	dry ice
CAS Number	103628-48-4
Molecular Formula	C₁₄H₂₁N₃O₂S • C₄H₆O₄
SMILES	CN(C)CCC1=CNC2=CC=C(CS(NC)(=O)=O)C=C21.O=C(CCC(O)=O)O
Molecular Weight	413,5
Formulation	A crystalline solid
Purity	≥98%
Custom Code	2922.19
UNSPSC code	12352100

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MSDS

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Cayman Chemical's mission is to help make research possible by supplying scientists worldwide with the basic research tools necessary for advancing human and animal health. Our utmost commitment to healthcare researchers is to offer the highest quality products with an affordable pricing policy.

Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.

Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.

Our organic and analytical chemists specialize in the rapid development of manufacturing processes and analytical methods to carry out clinical and commercial GMP-API production. Pre-clinical drug discovery efforts are currently underway in the areas of bone restoration and repair, muscular dystrophy, oncology, and inflammation. A separate group of Ph.D.-level scientists are dedicated to offering Hit-to-Lead Discovery and Profiling Services for epigenetic targets. Our knowledgeable chemists can be contracted to perform complete sample analysis for analytes measured by the majority of our assays. We also offer a wide range of analytical services using LC-MS/MS, HPLC, GC, and many other techniques.

Accreditations
ISO/IEC 17025:2005
ISO Guide 34:2009

Cayman is a leader in the field of emerging drugs of abuse, providing high-purity Schedule I-V Controlled Substances to federally-licensed laboratories and qualified academic research institutions for forensic analyses. We are certified by ACLASS Accreditation Services with dual accreditation to ISO/IEC 17025:2005 and ISO Guide 34:2009.