Thio-TEPA

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Thio-TEPA

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Cat No: 23745

Biochemicals - Dna Alkylating Agents

Thio-TEPA is an alkylating agent with anticancer activity (IC50 = 1.5 μM against P388 murine leukemia cells).{37276} It alkylates DNA and inhibits thymidine incorporation (IC50 = 2 μM) inducing irreversible DNA damage. Thio-TEPA crosslinks guanine nuc...

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Territorial Availability: Available through Bertin Technologies only in France

Synonyms:

1,1',1''-phosphinothioylidynetris-aziridine

Correlated keywords:

639-23-6 85177-92-0 1631739-26-8 AI 3-24916 AI324916 CBC-806495 CBC806495 Girostan thiotepa NCIC01649 NSC6396 Oncotepa Oncothio-tepa Oncotiotepa Phosphorothioic acid triethylenetriamide triamide SK6882 SK-6882 STEPA TESPA TSPA Tespamin Tespamine Thio-Tep Tio-TEF Thiotep Thiofozil Thiophosphamide Thioplex Thiotef Triaziridinylphosphine sulfide Tiofosfamid Tiofosyl Tiofozil triethyleneiminothiophosphoramide anti-cancer MCF7 L-1210 S91 Thiotriethylenephosphoramide Triethylenethiophosphorotriamide Tris(1-aziridinyl)phosphine Thiophosphoramide P-388

Product Overview:
Thio-TEPA is an alkylating agent with anticancer activity (IC50 = 1.5 μM against P388 murine leukemia cells).{37276} It alkylates DNA and inhibits thymidine incorporation (IC50 = 2 μM) inducing irreversible DNA damage. Thio-TEPA crosslinks guanine nucleotides and induces cell cycle arrest via the formation of interstrand crosslinks in L1210 and MCF-7 cancer cells in vitro.{37277} In vivo, thio-TEPA reduces the number of pulmonary metastases in mice following subcutaneous injection of melanoma cells.{37278} It also decreases the number of postoperative lung metastases when administered at a dose of 10 mg/kg after surgical removal of an S-91 melanoma tumor established via intramuscular injection in mice.

Size	250 mg
Shipping	dry ice
CAS Number	52-24-4
Molecular Formula	C₆H₁₂N₃PS
SMILES	S=P(N1CC1)(N2CC2)N3CC3
Molecular Weight	189,2
Formulation	A solid
Purity	≥98%
Custom Code	2930.90
UNSPSC code	12352100

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Cayman Chemical's mission is to help make research possible by supplying scientists worldwide with the basic research tools necessary for advancing human and animal health. Our utmost commitment to healthcare researchers is to offer the highest quality products with an affordable pricing policy.

Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.

Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.

Our organic and analytical chemists specialize in the rapid development of manufacturing processes and analytical methods to carry out clinical and commercial GMP-API production. Pre-clinical drug discovery efforts are currently underway in the areas of bone restoration and repair, muscular dystrophy, oncology, and inflammation. A separate group of Ph.D.-level scientists are dedicated to offering Hit-to-Lead Discovery and Profiling Services for epigenetic targets. Our knowledgeable chemists can be contracted to perform complete sample analysis for analytes measured by the majority of our assays. We also offer a wide range of analytical services using LC-MS/MS, HPLC, GC, and many other techniques.

Accreditations
ISO/IEC 17025:2005
ISO Guide 34:2009

Cayman is a leader in the field of emerging drugs of abuse, providing high-purity Schedule I-V Controlled Substances to federally-licensed laboratories and qualified academic research institutions for forensic analyses. We are certified by ACLASS Accreditation Services with dual accreditation to ISO/IEC 17025:2005 and ISO Guide 34:2009.