Chlorambucil

Biochemicals - DNA Alkylating Agents

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Cat No: 23744

Biochemicals - Dna Alkylating Agents

Chlorambucil is a nitrogen mustard alkylating agent that forms intra- and interstrand crosslinks in DNA, the latter of which prevents DNA replication and transcription leading to cell death.{36302} It preferentially decreases survival of rapidly proli...

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Territorial Availability: Available through Bertin Technologies only in France

Synonyms:

4-[bis(2-chloroethyl)amino]-benzenebutanoic acid

Correlated keywords:

CB1348 Ambochlorin Amboclorin Chloraminophene Chlorbutin Chlorobutine Ecloril Leukeran Linfolizin Linfolysin Lympholysin NCI3088 NSC3088 CLL

Product Overview:
Chlorambucil is a nitrogen mustard alkylating agent that forms intra- and interstrand crosslinks in DNA, the latter of which prevents DNA replication and transcription leading to cell death.{36302} It preferentially decreases survival of rapidly proliferating spleen colony-forming cells over spleen colony-forming cells from normal bone marrow.{36301} Formulations containing chlorambucil have been used alone and in combination with other chemotherapeutic agents in the treatment of chronic lymphocytic leukemia and lymphomas.

Size	250 mg
Shipping	dry ice
CAS Number	305-03-3
Molecular Formula	C₁₄H₁₉Cl₂NO₂
SMILES	OC(CCCC1=CC=C(N(CCCl)CCCl)C=C1)=O
Molecular Weight	304,2
Formulation	A solid
Purity	≥98%
Custom Code	2916.39
UNSPSC code	12352100

Technical File

MSDS

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Cayman Chemical's mission is to help make research possible by supplying scientists worldwide with the basic research tools necessary for advancing human and animal health. Our utmost commitment to healthcare researchers is to offer the highest quality products with an affordable pricing policy.

Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.

Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.

Our organic and analytical chemists specialize in the rapid development of manufacturing processes and analytical methods to carry out clinical and commercial GMP-API production. Pre-clinical drug discovery efforts are currently underway in the areas of bone restoration and repair, muscular dystrophy, oncology, and inflammation. A separate group of Ph.D.-level scientists are dedicated to offering Hit-to-Lead Discovery and Profiling Services for epigenetic targets. Our knowledgeable chemists can be contracted to perform complete sample analysis for analytes measured by the majority of our assays. We also offer a wide range of analytical services using LC-MS/MS, HPLC, GC, and many other techniques.

Accreditations
ISO/IEC 17025:2005
ISO Guide 34:2009

Cayman is a leader in the field of emerging drugs of abuse, providing high-purity Schedule I-V Controlled Substances to federally-licensed laboratories and qualified academic research institutions for forensic analyses. We are certified by ACLASS Accreditation Services with dual accreditation to ISO/IEC 17025:2005 and ISO Guide 34:2009.

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