Methimazole

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Methimazole

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Cat No: 23718

Biochemicals - More Biochemicals

Methimazole is an inhibitor of thyroid hormone synthesis.{37227,37226} It is a substrate for thyroid peroxidase that traps oxidized iodide, preventing its use by thyroglobulin for thyroid hormone synthesis. Methimazole (0.4 mg/kg) inhibits the absorpt...

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Territorial Availability: Available through Bertin Technologies only in France

Synonyms:

1,3-dihydro-1-methyl-2H-imidazole-2-thione

Correlated keywords:

4708-61-6 85916-84-3 BBW basolan Favistan Frentirox MMI Mercaptazole Mercazole Mercazolyl Metazolo Methimazol Methylmercaptoimidazole Metothyrin Metothyrine Metotirin N-Methyl-2-mercaptoimidazole NSC38608 Strumazol Tapazole Thacapzol Thiamazol Thiamazole Thycapzol Thymidazol Thymidazole Thyrozol Danantizol Metizol Methylimidazolethiol

Product Overview:
Methimazole is an inhibitor of thyroid hormone synthesis.{37227,37226} It is a substrate for thyroid peroxidase that traps oxidized iodide, preventing its use by thyroglobulin for thyroid hormone synthesis. Methimazole (0.4 mg/kg) inhibits the absorption of radiolabeled iodide by the thyroid gland in rats by 80.9%.{37225} It reduces the incidence of lymphocytic thyroiditis in the insulin-dependent type 1 diabetic BB/W rat.{37224} Methimazole has been used to induce hypothyroidism in mice.{59786,59787} Formulations containing methimazole have been used in the treatment of hyperthyroidism.

Size	50 mg
Shipping	wet ice
CAS Number	60-56-0
Molecular Formula	C₄H₆N₂S
SMILES	CN(C=CN1)C1=S
Molecular Weight	114,2
Formulation	A solid
Purity	≥98%
Custom Code	2930.90
UNSPSC code	12352100

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Cayman Chemical's mission is to help make research possible by supplying scientists worldwide with the basic research tools necessary for advancing human and animal health. Our utmost commitment to healthcare researchers is to offer the highest quality products with an affordable pricing policy.

Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.

Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.

Our organic and analytical chemists specialize in the rapid development of manufacturing processes and analytical methods to carry out clinical and commercial GMP-API production. Pre-clinical drug discovery efforts are currently underway in the areas of bone restoration and repair, muscular dystrophy, oncology, and inflammation. A separate group of Ph.D.-level scientists are dedicated to offering Hit-to-Lead Discovery and Profiling Services for epigenetic targets. Our knowledgeable chemists can be contracted to perform complete sample analysis for analytes measured by the majority of our assays. We also offer a wide range of analytical services using LC-MS/MS, HPLC, GC, and many other techniques.

Accreditations
ISO/IEC 17025:2005
ISO Guide 34:2009

Cayman is a leader in the field of emerging drugs of abuse, providing high-purity Schedule I-V Controlled Substances to federally-licensed laboratories and qualified academic research institutions for forensic analyses. We are certified by ACLASS Accreditation Services with dual accreditation to ISO/IEC 17025:2005 and ISO Guide 34:2009.