Thiothixene

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Thiothixene

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Cat No: 23649

Biochemicals - Receptor Pharmacology

Thiothixene is a typical antipsychotic.{39485} It selectively binds to dopamine D2 over D1, D3, and D4 receptors (Kis = 0.417, 338, 186.2, and 363.1 nM, respectively). Thiothixene also binds to various serotonin (5-HT), histamine H1, α1- and α2-adrene...

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Territorial Availability: Available through Bertin Technologies only in France

Synonyms:

N,N-dimethyl-9-[3-(4-methyl-1-piperazinyl)propylidene]-9H-thioxanthene-2-sulfonamide

Correlated keywords:

Navane Navan Navaron 4657-B P4657B CP12252 CP122521 122521 NSC108165 Thixit anti-psychotic tiotixene orbinamon

Product Overview:
Thiothixene is a typical antipsychotic.{39485} It selectively binds to dopamine D2 over D1, D3, and D4 receptors (Kis = 0.417, 338, 186.2, and 363.1 nM, respectively). Thiothixene also binds to various serotonin (5-HT), histamine H1, α1- and α2-adrenergic, muscarinic acetylcholine, and sigma receptors (Kis = 15-5,754 nM) as well as the dopamine, norepinephrine, and serotonin transporters (Kis = 3.16-30 μM). In vivo, thiothixene reduces spontaneous and amphetamine-induced locomotor activity in rats.{39486} It enhances latent inhibition, as measured by a decreased lick latency in response to light and foot shock stimuli, which is a measure of selective attention in rats.{39487} Thiothixene also increases competitive behavior in submissive mice, indicating antidepressant-like behavior.{39488} Formulations containing thiothixene have been used in the treatment of schizophrenia and bipolar mania.

Size	1 mg
Shipping	dry ice
CAS Number	5591-45-7
Molecular Formula	C₂₃H₂₉N₃O₂S₂
SMILES	CN1CCN(CC/C=C2C(C=CC=C3)=C3SC4=C\2C=C(S(N(C)C)(=O)=O)C=C4)CC1
Molecular Weight	443,6
Formulation	A crystalline solid
Purity	≥98%
Custom Code	2933.59
UNSPSC code	12352100

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