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Peptide YY (PYY) is a polypeptide that is released postprandially in proportion to meal energy content by endocrine L cells in the ileum and colon in order to regulate appetite.{24276} PYY, along with neuropeptide Y (NPY; Item No. 15071), inhibits gastrointestinal motility and electrolyte secretion, which is thought to indicate satiety through a potent feedback signal on hypothalamic circuits.{24276,27059} Upon release, PYY is cleaved to PYY (3-36), which is a preferred agonist at presynaptic inhibitory type 2 NPY autoreceptors (EC50 = 11.4 nM in human colon mucosa).{27058} PYY (3-36) has been associated with dose-dependent weight loss in various obesity models including ob/ob mice, diet-induced obese mice, and non-diabetic fatty Zucker rats.{27059}
Territorial Availability: Available through Bertin Technologies only in France
| Size | 1 mg, 500 µg |
|---|---|
| Shipping | dry ice |
| CAS number | 123583-37-9 |
| Molecular formula | C180H279N53O54 |
| Smiles | NC([C@@H](NC([C@H](CCCNC(N)=N)NC([C@H](CCC(N)=O)NC([C@H](CCCNC(N)=N)NC([C@@]([C@@H](C)O)([H])NC([C@H](C(C)C)NC([C@H](CC(C)C)NC([C@H](CC(N)=O)NC([C@H](CC(C)C)NC([C@@H](NC([C@@H](NC([C@H](CCCNC(N)=N)NC([C@H](CC(C)C)NC([C@H](CO)NC([C@@H](NC([C@@H](NC([C@@H](NC([C@H](CCCNC(N)=N)NC([C@H](CC(N)=O)NC([C@H](CC(C)C)NC([C@H](CCC(O)=O)NC([C@H](CCC(O)=O)NC([C@@H]1CCCN1C([C@H](CO)NC([C@@H](NC([C@@H](NC([C@H](CCC(O)=O)NC(CNC([C@@H]2CCCN2C([C@@H](NC([C@H](CCC(O)=O)NC([C@@H]3CCCN3C([C@H](CCCCN)NC([C@@]([C@H](CC)C)([H])N[H])=O)=O)=O)=O)C)=O)=O)=O)=O)CC(O)=O)=O)C)=O)=O)=O)=O)=O)=O)=O)=O)CC4=CC=C(O)C=C4)=O)CC5=CC=C(O)C=C5)=O)C)=O)=O)=O)=O)CC6=CN=CN6)=O)CC7=CC=C(O)C=C7)=O)=O)=O)=O)=O)=O)=O)=O)=O)CC8=CC=C(O)C=C8)=O |
| Molecular weight | 4049,5 |
| Custom code | 3504.00 |
| Formulation | A lyophilized powder |
| Purity | ≥95% |
| UNSPSC code | 12352204 |
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