€615.00 €522.75
Neprilysin, also known as CD10, is a type II transmembrane glycoprotein and zinc-dependent endopeptidase encoded by MME in humans.{58211,58210} It is composed of an extracellular domain that contains the endopeptidase active site, a transmembrane domain, and a short cytoplasmic tail. Neprilysin is expressed transiently during B cell maturation and is constitutively expressed in a variety of tissues including lung, intestine, kidney, liver, breast, and the CNS. It cleaves a variety of substrates, including enkephalins, substance P, angiotensin, oxytocin, somatostatin, and bombesins, and has roles in CNS development, pain perception, spatial working memory, fetal development, airway inflammation, and stem cell differentiation. MME expression is associated with increased 5-year survival rates in pediatric patients with B cell lineage acute lymphoblastic leukemia (ALL) and inversely correlated with poor prognosis in patients with various types of solid tumors.{58210} Neprilysin protein levels and enzymatic activity are decreased in postmortem brain tissue from patients with Alzheimer’s disease. Cayman’s Neprilysin/CD10 (N-Term) Rabbit Monoclonal Antibody can be used for immunohistochemistry (IHC) and Western blot (WB) applications.
Territorial Availability: Available through Bertin Technologies only in France
| Size | 100 µl |
|---|---|
| Shipping | dry ice |
| Molecular weight | 0 |
| Host | Rabbit |
| Antigen | Peptide from the N-terminal region of human neprilysin |
| Clone | RM337 |
| Isotype | IgG |
| Application(s) | IHC, WB |
| Formulation | 100 µl of protein A-affinity purified monoclonal antibody |
| Custom code | 3822.19 |
| UNSPSC code | 12352203 |
Cayman Chemical’s mission is to help make research possible by supplying scientists worldwide with the basic research tools necessary for advancing human and animal health. Our utmost commitment to healthcare researchers is to offer the highest quality products with an affordable pricing policy.
Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.
Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.
Our organic and analytical chemists specialize in the rapid development of manufacturing processes and analytical methods to carry out clinical and commercial GMP-API production. Pre-clinical drug discovery efforts are currently underway in the areas of bone restoration and repair, muscular dystrophy, oncology, and inflammation. A separate group of Ph.D.-level scientists are dedicated to offering Hit-to-Lead Discovery and Profiling Services for epigenetic targets. Our knowledgeable chemists can be contracted to perform complete sample analysis for analytes measured by the majority of our assays. We also offer a wide range of analytical services using LC-MS/MS, HPLC, GC, and many other techniques.
Accreditations
ISO/IEC 17025:2005
ISO Guide 34:2009
Cayman is a leader in the field of emerging drugs of abuse, providing high-purity Schedule I-V Controlled Substances to federally-licensed laboratories and qualified academic research institutions for forensic analyses. We are certified by ACLASS Accreditation Services with dual accreditation to ISO/IEC 17025:2005 and ISO Guide 34:2009.
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