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Maytansine is an ansa macrolide originally isolated from M. serrata that has anticancer activity.{58875} It inhibits the growth of L1210, L-5178-Y, and P388 murine leukemia cells (EC50s = 0.6, 12, and 1.5 nM, respectively). Maytansine (20 µM) inhibits erythrocyte and brain tubulin polymerization.{58876} In vivo, maytansine (0.025-0.1 mg/kg) increases survival in a P388 murine leukemia model.{58875} It has also been used in the synthesis of cytotoxic payload moieties of antibody-drug conjugates (ADCs).{58877}
Territorial Availability: Available through Bertin Technologies only in France
| Size | 1 mg, 10 mg, 5 mg, 500 µg |
|---|---|
| Shipping | dry ice |
| CAS number | 35846-53-8 |
| Molecular formula | C34H46ClN3O10 |
| Smiles | C[C@]12[C@@]([C@@H]([C@]3([H])C[C@]([C@@H](/C=C/C=C(CC4=CC(N(C(C[C@@H]2OC([C@H](C)N(C)C(C)=O)=O)=O)C)=C(Cl)C(OC)=C4)C)OC)(NC(O3)=O)O)C)([H])O1, C[C@]12[C@@]([C@@H]([C@]3([H])C[C@]([C@@H](/C=C/C=C(CC4=CC(N(C(C[C@@H]2OC([C@H](C)N(C)C(C)=O)=O)=O)C)=C(Cl)C(OC)=C4)C)OC)(NC(O3)=O)O)C)([H])O1, C[C@]12[C@@]([C@@H]([C@]3([H])C[C@]([C@@H](/C=C/C=C(CC4=CC(N(C(C[C@@H]2OC([C@H](C)N(C)C(C)=O)=O)=O)C)=C(Cl)C(OC)=C4)C)OC)(NC(O3)=O)O)C)([H])O1, C[C@]12[C@@]([C@@H]([C@]3([H])C[C@]([C@@H](/C=C/C=C(CC4=CC(N(C(C[C@@H]2OC([C@H](C)N(C)C(C)=O)=O)=O)C)=C(Cl)C(OC)=C4)C)OC)(NC(O3)=O)O)C)([H])O1 |
| Molecular weight | 692,2 |
| Custom code | 2934.99 |
| Formulation | A solid |
| Purity | ≥98% |
| UNSPSC code | 12352100 |
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Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.
Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.
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