Leukotriene E<sub>4</sub>-<wbr/>d<sub>5</sub>

Leukotriene E4–d5

CAT N°: 10007858
Price:

414.00 351.90

Leukotriene E4-d5 (LTE4-d5) contains five deuterium atoms at the 19, 19′, 20, 20 and 20 positions. It is intended for use as an internal standard for the quantification of LTE4 by GC- or LC-mass spectrometry. LTE4 is produced by the action of dipeptidase on LTD4, leaving only the cysteinyl group still attached to the fatty acid backbone.{2236} It is one of the constituents of slow-reacting substance of anaphylaxis (SRS-A).{394} LTE4 is considerably less active (8 to 12-fold) than LTC4 in the biological activities characteristic of cysteinyl leukotrienes.{2236,396} Unlike LTC4 and LTD4, LTE4 accumulates in both plasma and urine. Therefore, urinary excretion of LTE4 is most often used as an indicator of asthma.{1815,865,2064} In humans, basal levels of LTE4 range from 1-100 pg/mg creatinine. In asthmatic patients, urinary LTE4 levels increase to 80-1,000 pg/mg creatinine.{865}

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