From €134.00 €113.90
Koumine is an alkaloid that has been found in Gelsemium elegans and has diverse biological activities.{62600,62601,62602,62603} It inhibits the proliferation of MCF-7 breast cancer cells (IC50 = 124 µg/ml) as well as induces apoptosis and cell cycle arrest at the G2/M phase in the same cells.{62600} Koumine (200 and 400 µg/ml) reduces LPS-induced increases in inducible nitric oxide synthase (iNOS), IL-1?, IL-6, and TNF-? levels in RAW 264.7 macrophages.{62601} It inhibits acetic acid-induced writhing and formalin-induced paw licking and biting in mice when administered at doses of 2 and 10 mg/kg.{62602} Koumine (0.4-10 mg/kg) increases the number of entries into and percentage of time spent in the open arms of the elevated plus maze in mice, indicating anxiolytic-like activity.{62603}
Territorial Availability: Available through Bertin Technologies only in France
| Size | 1 mg, 10 mg, 25 mg, 5 mg |
|---|---|
| Shipping | dry ice |
| CAS number | 1358-76-5 |
| Molecular formula | C20H22N2O |
| Smiles | C=C[C@@]1(CN2C)[C@]3(C[C@@]2([H])[C@]4([H])[C@@]1([H])C[C@@]5([H])OC4)C5=NC6=CC=CC=C36 |
| Molecular weight | 306,4 |
| Custom code | 2933.99 |
| Formulation | A solid |
| Purity | ≥98% |
| UNSPSC code | 12352100 |
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Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.
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