€615.00 €522.75
c-Jun N-terminal kinases (JNKs) are stress-activated serine/threonine protein kinases and members of the MAPK family with roles in cell proliferation, differentiation, apoptosis, and migration.{55665,55664} JNKs are encoded by three distinct genes, JNK1, JNK2, and JNK3, which produce 10 variants via alternative splicing. JNK1 and JNK2 are ubiquitously expressed while JNK3 is expressed at high levels in the CNS and low levels in cardiac smooth muscle and the testis.{55665} In response to stress stimuli, such as osmotic or UV shock, cytokines, or growth factor signaling, JNKs are activated by phosphorylation at threonine 183 (Thr183) and tyrosine 185 (Tyr185) by MKK7 and MKK4, respectively, in a synergistic manner, and induce various transcription factor-mediated downstream signaling events.{55667,55665} Neuronal levels of JNK (phospho- Thr183/Tyr185) are increased in mouse models of sporadic and prion-induced Alzheimer’s disease.{55666} Renal JNK (phospho- Thr183/Tyr185) levels are increased in patients with glomerulonephritis and diabetic neuropathy and are associated with the degree of glomerulosclerosis and macrophage infiltration.{55664} Cayman’s JNK1/2/3 (Phospho-Thr183/Tyr185) Rabbit Monoclonal Antibody can be used for immunohistochemistry (IHC) and Western blot (WB) applications.
Territorial Availability: Available through Bertin Technologies only in France
| Size | 100 µl |
|---|---|
| Shipping | dry ice |
| Molecular weight | 0 |
| Host | Rabbit |
| Antigen | Peptide corresponding to human JNK1/2/3 (phospho-Thr183/Tyr185) |
| Clone | RM464 |
| Isotype | IgG |
| Application(s) | IHC, WB |
| Formulation | 100 µl of protein A-affinity purified monoclonal antibody |
| Custom code | 3822.19 |
| UNSPSC code | 12352203 |
Cayman Chemical’s mission is to help make research possible by supplying scientists worldwide with the basic research tools necessary for advancing human and animal health. Our utmost commitment to healthcare researchers is to offer the highest quality products with an affordable pricing policy.
Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.
Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.
Our organic and analytical chemists specialize in the rapid development of manufacturing processes and analytical methods to carry out clinical and commercial GMP-API production. Pre-clinical drug discovery efforts are currently underway in the areas of bone restoration and repair, muscular dystrophy, oncology, and inflammation. A separate group of Ph.D.-level scientists are dedicated to offering Hit-to-Lead Discovery and Profiling Services for epigenetic targets. Our knowledgeable chemists can be contracted to perform complete sample analysis for analytes measured by the majority of our assays. We also offer a wide range of analytical services using LC-MS/MS, HPLC, GC, and many other techniques.
Accreditations
ISO/IEC 17025:2005
ISO Guide 34:2009
Cayman is a leader in the field of emerging drugs of abuse, providing high-purity Schedule I-V Controlled Substances to federally-licensed laboratories and qualified academic research institutions for forensic analyses. We are certified by ACLASS Accreditation Services with dual accreditation to ISO/IEC 17025:2005 and ISO Guide 34:2009.
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