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Ginsenoside Rg1 is a steroid glycoside that has been found in P. ginseng and has diverse biological activities.{64376,64377,64378,64379} In vivo, ginsenoside Rg1 (10, 20, and 40 mg/kg) decreases blood glucose, IL-1?, and IL-18 levels, increases insulin secretion, and inhibits hepatic and pancreatic activation of the NLRP3 inflammasome in a mouse model of diabetes induced by streptozotocin (STZ; Item No. 13104).{64376} It facilitates fear extinction and decreases immobility time in the tail-suspension and forced swim tests in a mouse model of single-prolonged stress-induced post-traumatic stress disorder (PTSD).{64377} Ginsenoside Rg1 decreases hepatic alanine transaminase (ALT) and aspartate aminotransferase (AST) levels and attenuates hepatic steatosis in a mouse model of ethanol-induced hepatitis.{64378} It also decreases the abundance of Bacteroidetes in the large intestine, cortical neuron apoptosis, and latency to the platform in the Morris water maze in a tree shrew model of Alzheimer’s disease induced by amyloid-? (25-35) (A? (25-35)).{64379}
Territorial Availability: Available through Bertin Technologies only in France
| Size | 1 mg, 10 mg, 25 mg, 5 mg |
|---|---|
| Shipping | dry ice |
| CAS number | 22427-39-0 |
| Molecular formula | C42H72O14 |
| Smiles | O[C@H]1[C@@]2([H])[C@](CC[C@]2([H])[C@@](CC/C=C(C)/C)(C)O[C@@H]3O[C@H](CO)[C@@H](O)[C@H](O)[C@H]3O)(C)[C@]4(C)C[C@H](O[C@]5([H])O[C@H](CO)[C@@H](O)[C@H](O)[C@H]5O)[C@]6([H])[C@@](CC[C@H](O)C6(C)C)(C)[C@@]4([H])C1 |
| Molecular weight | 801 |
| Custom code | 2932.99 |
| Formulation | A crystalline solid |
| Purity | ≥98% |
| UNSPSC code | 12352100 |
Cayman Chemical’s mission is to help make research possible by supplying scientists worldwide with the basic research tools necessary for advancing human and animal health. Our utmost commitment to healthcare researchers is to offer the highest quality products with an affordable pricing policy.
Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.
Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.
Our organic and analytical chemists specialize in the rapid development of manufacturing processes and analytical methods to carry out clinical and commercial GMP-API production. Pre-clinical drug discovery efforts are currently underway in the areas of bone restoration and repair, muscular dystrophy, oncology, and inflammation. A separate group of Ph.D.-level scientists are dedicated to offering Hit-to-Lead Discovery and Profiling Services for epigenetic targets. Our knowledgeable chemists can be contracted to perform complete sample analysis for analytes measured by the majority of our assays. We also offer a wide range of analytical services using LC-MS/MS, HPLC, GC, and many other techniques.
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Cayman is a leader in the field of emerging drugs of abuse, providing high-purity Schedule I-V Controlled Substances to federally-licensed laboratories and qualified academic research institutions for forensic analyses. We are certified by ACLASS Accreditation Services with dual accreditation to ISO/IEC 17025:2005 and ISO Guide 34:2009.
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