Firocoxib

Firocoxib

CAT N°: 28286
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Firocoxib is a selective inhibitor of COX-2 (IC50s = 0.13 and 7.5 µM for COX-2 and COX-1, respectively, in isolated cat blood).{50228} It inhibits LPS-induced production of prostaglandin E2 (PGE2; Item No. 14010) in isolated dog, horse, and cat whole blood ex vivo.{50230,50231,50228} Firocoxib decreases lameness, induces analgesia, and improves range of motion in dogs and horses with osteoarthritis when administered at doses of 5 and 0.1 mg/kg per day, respectively.{50232,50233} Formulations containing firocoxib have been used in dogs and horses with osteoarthritis.

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