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Filipin complex is a neutral polyene originally isolated from S. filipinensis with antifungal activity.{42119} It inhibits cell growth as well as mitochondrial terminal electron transport in S. cerevisiae when used at a concentration of 135 µg/ml. Filipin complex binds to various sterols, particularly 24?-methyl cholesterol (Item no. 17344), 24?-ethyl cholesterol (Item no. 11756), and cholesterol, in aqueous solutions and in fungal cell membranes when used at a concentration of 50 µg/ml, inducing membrane pit formation and leakage of cell contents.{42120,9103,42106} It is a fluorescent compound that has been used to label sterols within biological structures for imaging.{9103,8625,42104,42105} Filipin complex displays excitation/emission maxima of 338/480 nm, respectively.
Territorial Availability: Available through Bertin Technologies only in France
| Size | 25 mg, 5 mg |
|---|---|
| Shipping | dry ice |
| CAS number | 11078-21-0 |
| Molecular formula | C35H58O11 (for Filipin III) |
| Smiles | O[C@@H]1/C(C)=C/C=C/C=C/C=C/C=C/C[C@@H](C)OC([C@@](CCCCCC)([H])[C@@H](O)C[C@@H](O)C[C@@H](O)C[C@@H](O)C[C@@H](O)C[C@@H](O)C1)=O.O[C@@H]2/C(C)=C/C=C/C=C/C=C/C=C/[C@H](O)[C@@H](C)OC([C@@]([C@H](O)CCCCC)([H])[C@@H](O)C[C@@H](O)C[C@@H](O)C[C@@H](O)C[C@@H](O)C[C@@H](O)C2)=O.O[C@@H]3/C(C)=C/C=C/C=C/C=C/C=C/[C@H](O)[C@@H](C)OC([C@@](CCCCCC)([H])[C@@H](O)C[C@@H](O)C[C@@H](O)C[C@@H](O)C[C@@H](O)C[C@@H](O)C3)=O |
| Molecular weight | 654,8 |
| Custom code | 2932.99 |
| Formulation | A solid |
| Purity | ≥95% |
| UNSPSC code | 12352100 |
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