€818.00 €695.30
Diphtheria toxin CRM197 mutant from C. diphtheriae is an inactive and non-toxic version of diphtheria toxin (Item No. 19657). It contains a single base change in the structural gene resulting in the substitution of glutamic acid for glycine which blocks ADP-ribosylation.{38537} Diphtheria toxin CRM197 mutant has no enzymatic activity but is immunologically indistinguishable from diphtheria toxin. Formulations containing diphtheria toxin CRM197 mutant have been used as carriers of conjugated polysaccharides in the development of vaccines against encapsulated bacterial pathogens.{38538}
Territorial Availability: Available through Bertin Technologies only in France
| Size | 250 µg |
|---|---|
| Shipping | wet ice |
| Molecular weight | 0 |
| Formulation | Each vial, when reconstituted to 0.25 ml with water, contains 250 µg of diphtheria toxin CRM197 mutant in 0.01 M sodium phosphate with 5% lactose at pH 7.4 |
| Purity | ≥90% estimated by SDS-PAGE |
| Custom code | 3504.00 |
| UNSPSC code | 12352204 |
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Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.
Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.
Our organic and analytical chemists specialize in the rapid development of manufacturing processes and analytical methods to carry out clinical and commercial GMP-API production. Pre-clinical drug discovery efforts are currently underway in the areas of bone restoration and repair, muscular dystrophy, oncology, and inflammation. A separate group of Ph.D.-level scientists are dedicated to offering Hit-to-Lead Discovery and Profiling Services for epigenetic targets. Our knowledgeable chemists can be contracted to perform complete sample analysis for analytes measured by the majority of our assays. We also offer a wide range of analytical services using LC-MS/MS, HPLC, GC, and many other techniques.
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