24(S),25-epoxy Cholesterol
24(S),25-epoxy Cholesterol
24(S),25-epoxy Cholesterol is an oxysterol and the most abundant oxysterol in mouse ventral midbrain.{43943} It activates liver X receptors (LXRs)...
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Dehydrolithocholic acid is a major metabolite of lithocholic acid (LCA; Item No. 20253).{48226} It is formed from LCA by the cytochrome P450 (CYP) isoform CYP3A4. Dehydrolithocholic acid is an agonist of G protein-coupled bile acid activated receptor 1 (GP-BAR1/TGR5; EC50 = 0.27 ?M), vitamin D receptor (VDR; EC50 = 3 ?M), and farnesoid X receptor (FXR) in cell-based reporter assays.{53582,10150} It also binds to the human pregnane X receptor (PXR; IC50 = 15 ?M) and activates mouse and human PXRs in cell-based reporter assays when used at a concentration of 100 ?M.{32396} Dehydrolithocholic acid binds to retinoic acid receptor-related orphan receptor ?t (ROR?t; Kd = 1.13 ?M for the recombinant human ligand-binding domain) and decreases its activity in a cell-based reporter assay when used at a concentration of 10 ?M.{53583} It inhibits the differentiation of T helper cells that express IL-17a (TH17 cells) when used at a concentration of 20 ?M.
Territorial Availability: Available through Bertin Technologies only in France
Size | 10 mg, 100 mg, 250 mg, 50 mg |
---|---|
Shipping | dry ice |
CAS number | 1553-56-6 |
Molecular formula | C24H38O3 |
Smiles | C[C@H](CCC(O)=O)[C@@]1([H])CC[C@@]2([H])[C@]3([H])CC[C@]4([H])CC(CC[C@]4(C)[C@@]3([H])CC[C@@]21C)=O |
Molecular weight | 374,6 |
Custom code | 2918.19 |
Formulation | A crystalline solid |
Purity | ≥95% |
UNSPSC code | 12352100 |
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