Cyclo(Phe-Pro)

Cyclo(Phe-Pro)

CAT N°: 34758
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Cyclo(Phe-Pro) is a bacterial quorum-sensing molecule that has been found in V. cholerae.{64107} It enhances ToxR-dependent transcription of leuO, a DNA binding protein, and inhibits virulence factor production in V. cholerae. Cyclo(Phe-Pro) is an inhibitor of the interaction between retinoic acid-inducible gene I (RIG-I) and the ubiquitin ligase TRIM25.{64108} It increases the viral load in Huh7 cells infected with hepatitis C virus (HCV) when used at concentrations of 1, 2.5, and 5 mM. Cyclo(Phe-Pro) (50 mg/kg) reduces the expression of IFN-? induced by poly(I:C) and increases serum HCV titers in animal models of HCV infection.

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