CP 91,149

CP 91,149

CAT N°: 17709
Price:

From 92.00 78.20

CP 91,149 is an inhibitor of human liver glycogen phosphorylase a (LGPa), muscle glycogen phosphorylase a (MGPa), and MGPb (IC50s = 0.13, 0.2, and 0.3 ?M, respectively, in the presence of glucose).{41399,41400,41401} CP 91,149 is 5- to 10-fold less potent in the absence of glucose.{41399} In vitro, it inhibits glucagon-stimulated glycogenolysis in primary human hepatocytes (IC50 = 2.1 ?M) and increases glycogen synthesis in rat hepatocytes at a concentration of 2.5 ?M in the presence of 5 mM glucose.{41399,41401} CP 91,149 inhibits brain GP (IC50 = 0.5 ?M) and, at a concentration of 30 ?M, inhibits glycogen accumulation and proliferation of A549 non-small cell lung carcinoma (NSCLC) cells that express endogenous brain GP.{41402} In vivo, CP 91,149 (25 mg/kg, p.o.) lowers the plasma glucose level in diabetic ob/ob mice within 3 hours of administration without producing hypoglycemia, but has no effect on normoglycemic, non-diabetic mice.{41399}

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