α-Conotoxin ImI (trifluoro<wbr/>acetate salt)

α-Conotoxin ImI (trifluoroacetate salt)

CAT N°: 34022
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From 92.00 78.20

?-Conotoxin ImI is a conotoxin that has been found in C. imperialis and has receptor antagonist and anticancer activities.{62392} It is a peptide antagonist of homomeric ?7 nicotinic acetylcholine receptors (nAChRs; IC50 = 220 nM). ?-Conotoxin ImI is selective for ?7 nAChRs over ?2?2, ?3?2, ?4?2, ?2?4, ?3?4, ?4?4, and ?1?1?? subunit-containing nAChRs at 5 µM but does inhibit homomeric ?9 nAChRs (IC50 = 1,800 nM). Administration of paclitaxel (Item No. 10461) in micelles containing ?-conotoxin ImI decreases tumor growth in an MCF-7 mouse xenograft model.{62393} Intracerebroventricular, but not intraperitoneal, administration of ?-conotoxin ImI (20 nmol/animal) induces seizures in rats.{62394}

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