Supporting Your Research Beyond Traditional Models
Prion disease research now extends far beyond traditional models such as mice and hamsters. Research and surveillance programmes increasingly involve a wide range of mammalian species, from ruminants to camelids.
In this context, an antibody’s ability to recognise its target across different species becomes a key consideration.
The anti-PrP monoclonal antibodies SAF32 (A03202) and Sha31 (A03213) have documented use across a broad range of species in the scientific literature, providing a solid foundation for comparative studies and surveillance programmes.
Two Complementary Antibodies
SAF32 targets the N-terminal region of the PrP protein, specifically the octapeptide repeat domain. Its use has been documented in several species, including humans, mice, dromedary camels and the red-tailed phascogale.
Sha31, meanwhile, recognises the α1 helix within the C-terminal globular domain. Its conserved epitope contributes to its widespread use in PrP detection studies and TSE surveillance programmes.
For More Consistent Studies
The documented species coverage of these two clones helps minimise reagent changes when moving from one animal model to another and facilitates multi-species studies by allowing the use of the same detection antibody.
This approach helps reduce experimental variability and improves the comparability of results within a single research project.
Versatility Demonstrated in the Scientific Literature
Several publications highlight the use of SAF32 and Sha31 in a variety of experimental settings, including studies involving sheep, cattle, white-tailed deer, raccoons and dromedary camels:
- Vilette et al. (2016): Sha31 was used to detect PrP^res from multiple species within the same study,
- Cassmann et al. (2022): Sha31 was employed in research investigating the transmission of Chronic Wasting Disease (CWD) in white-tailed deer,
- Amara et al. (2025): SAF32 and Sha31 were used together in the first characterisation of prion disease in the dromedary camel.
Discover the documented species coverage of SAF32 (A03202) and Sha31 (A03213) and identify the anti-PrP antibody best suited to your research applications.