Azelaoyl PAF

Azelaoyl PAF

CAT N°: 60924
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Oxidized low-density lipoprotein (oxLDL) particles contain low molecular weight species which promote the differentiation of monocytes via the nuclear receptor PPAR?.{8499} One of these substances was recently isolated and purified from oxLDL, and identified as azelaoyl PAF.{8953} Azelaoyl PAF is a potent PPAR? agonist which competes for the thiazolidinedione binding site. Azelaoyl PAF is more potent than 15-deoxy-?12,14-prostaglandin J2, and equipotent with rosiglitazone as a ligand for this receptor.{8953}

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