WRW4 (trifluoro<wbr/>acetate salt)

WRW4 (trifluoroacetate salt)

CAT N°: 36763
Price:

From €66.00 €56.10

WRW4 is a peptide antagonist of formyl peptide receptor 2 (FPR2; IC50 = 0.23 µM) and FPR3, previously known as FPR-like 1 (FPRL1) and FPRL2, respectively.{65277,65278} It inhibits increases in intracellular calcium and chemotaxis induced by the FPR1 and FPR2 agonist WKYMVm (Item No. 33589) in RBL-2H3 cells expressing FPR2 and by the FPR3 agonist F2L in isolated human monocytes when used at a concentration of 10 µM. WRW4 (10 µM) also prevents the production of superoxide induced by amyloid-? (1-42) (A?42; Item No. 20574) in isolated human neutrophils.{65277} In vivo, WRW4 (1 mg/kg) increases lung edema and bronchoalveolar lavage fluid (BALF) protein levels in the absence and presence of the antibiotic ceftriaxone (Item No. 18866) in a mouse model of acute lung injury induced by S. pneumoniae.{65279}

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