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Sulthiame is a pan-inhibitor of carbonic anhydrases (CA; Kis = 6-1,540 nM for CAI, -II, and IV-XIV) and an anticonvulsant.{64413} It is selective for these CAs over CAIII (Ki = 630 µM). Sulthiame (10 µg/ml) also inhibits voltage-gated sodium currents in isolated guinea pig hippocampal CA1 neurons.{64414} It reduces epileptiform activity induced by 4-aminopyridine (Item No. 18511) in guinea pig hippocampal slices when used at a concentration of 2.5 mM.{64415} Sulthiame (100-300 mg/kg, i.p.) induces neuronal cell death in neonatal rats.{64416} It decreases forelimb clonus duration in a rat model of partial epilepsy induced by amygdaloid kindling when administered at doses ranging from 25 to 200 mg/kg.{64417} Formulations containing sulthiame have been used in the treatment of epilepsy.
Territorial Availability: Available through Bertin Technologies only in France
| Size | 1 mg, 10 mg, 25 mg, 5 mg |
|---|---|
| Shipping | dry ice |
| CAS number | 61-56-3 |
| Molecular formula | C10H14N2O4S2 |
| Smiles | O=S(N)(C1=CC=C(N2CCCCS2(=O)=O)C=C1)=O |
| Molecular weight | 290,4 |
| Custom code | 2935.90 |
| Formulation | A solid |
| Purity | ≥95% |
| UNSPSC code | 12352100 |
Cayman Chemical’s mission is to help make research possible by supplying scientists worldwide with the basic research tools necessary for advancing human and animal health. Our utmost commitment to healthcare researchers is to offer the highest quality products with an affordable pricing policy.
Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.
Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.
Our organic and analytical chemists specialize in the rapid development of manufacturing processes and analytical methods to carry out clinical and commercial GMP-API production. Pre-clinical drug discovery efforts are currently underway in the areas of bone restoration and repair, muscular dystrophy, oncology, and inflammation. A separate group of Ph.D.-level scientists are dedicated to offering Hit-to-Lead Discovery and Profiling Services for epigenetic targets. Our knowledgeable chemists can be contracted to perform complete sample analysis for analytes measured by the majority of our assays. We also offer a wide range of analytical services using LC-MS/MS, HPLC, GC, and many other techniques.
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