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N-desmethyl Galantamine is an alkaloid that has been found in C. asiaticum and is an active metabolite of galantamine (Item No. 17559).{62640,62641,62642,62643,62644} It inhibits acetylcholinesterase (AChE; IC50 = 0.23 µM) and currents induced by ACh (Item No. 23829) by 64.8% in Xenopus oocytes expressing human ?7 nicotinic acetylcholine receptors (nAChRs) when used at a concentration of 100 µM.{62641} N-desmethyl Galantamine is cytotoxic to MOLT-4 acute lymphoblastic leukemia cells and LMTK alveolar fibroblasts (IC50s = 0.6 and 0.5 µg/ml, respectively).{62643} It decreases disease severity in a mouse model of acute liver injury induced by carbon tetrachloride when administered at doses of 1 and 10 mg/kg.{62644}
Territorial Availability: Available through Bertin Technologies only in France
| Size | 1 mg, 10 mg, 5 mg |
|---|---|
| Shipping | dry ice |
| CAS number | 41303-74-6 |
| Molecular formula | C16H19NO3 |
| Smiles | COC1=C2C3=C(C=C1)CNCC[C@@]34[C@@](C[C@H](C=C4)O)([H])O2 |
| Molecular weight | 273,3 |
| Custom code | 2932.99 |
| Formulation | A solid |
| Purity | ≥90% |
| UNSPSC code | 12352100 |
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Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.
Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.
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