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Gypenoside XVII is a saponin that has been found in P. notoginseng and has diverse biological activities.{63157,63158,63159,63160} It induces autophagic clearance of amyloid-? precursor protein (APP), A?40, and A?42 in PC12 cells expressing Swedish mutant APP isoform 695 (APP695 Swe) when used at a concentration of 10 µM.{63157} Gypenoside XVII (40 mg/kg) prevents the formation of hippocampal and cortical A? plaques and ameliorates spatial cognitive deficits in the transgenic APP/PS1 mouse model of Alzheimer’s disease. It decreases lipid deposition in the aortic sinus and serum levels of malondialdehyde (MDA), reduces aortic plaque area, and increases serum levels of superoxide dismutase (SOD), glutathione peroxidase (GPX), and catalase in ApoE-/- mice.{63158} Gypenoside XVII (10 and 50 mg/kg) reduces spinal cord edema and neuronal apoptosis in a mouse model of mechanical compression-induced spinal cord injury.{63159} It also maintains retinal permeability and structure and reduces retinal levels of apoptotic proteins in a db/db mouse model of early diabetic retinopathy.{63160}
Territorial Availability: Available through Bertin Technologies only in France
| Size | 1 mg, 10 mg, 25 mg, 5 mg |
|---|---|
| Shipping | dry ice |
| CAS number | 80321-69-3 |
| Molecular formula | C48H82O18 |
| Smiles | C[C@]12[C@]3([C@@]([C@@H](C[C@]1([H])[C@@]4([C@@](C(C)([C@H](CC4)O[C@@H]5O[C@@H]([C@H]([C@@H]([C@H]5O)O)O)CO)C)([H])CC2)C)O)([H])[C@]([C@](O[C@@H]6O[C@H](CO[C@H]7[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O7)[C@@H](O)[C@H](O)[C@H]6O)(C)CC/C=C(C)/C)([H])CC3)C |
| Molecular weight | 947,2 |
| Custom code | 2938.90 |
| Formulation | A solid |
| Purity | ≥98% |
| UNSPSC code | 12352100 |
Cayman Chemical’s mission is to help make research possible by supplying scientists worldwide with the basic research tools necessary for advancing human and animal health. Our utmost commitment to healthcare researchers is to offer the highest quality products with an affordable pricing policy.
Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.
Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.
Our organic and analytical chemists specialize in the rapid development of manufacturing processes and analytical methods to carry out clinical and commercial GMP-API production. Pre-clinical drug discovery efforts are currently underway in the areas of bone restoration and repair, muscular dystrophy, oncology, and inflammation. A separate group of Ph.D.-level scientists are dedicated to offering Hit-to-Lead Discovery and Profiling Services for epigenetic targets. Our knowledgeable chemists can be contracted to perform complete sample analysis for analytes measured by the majority of our assays. We also offer a wide range of analytical services using LC-MS/MS, HPLC, GC, and many other techniques.
Accreditations
ISO/IEC 17025:2005
ISO Guide 34:2009
Cayman is a leader in the field of emerging drugs of abuse, providing high-purity Schedule I-V Controlled Substances to federally-licensed laboratories and qualified academic research institutions for forensic analyses. We are certified by ACLASS Accreditation Services with dual accreditation to ISO/IEC 17025:2005 and ISO Guide 34:2009.
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