From €505.00 €429.25
Aminoacyl tRNA synthase complex-interacting multifunctional protein 1 (AIMP1), also known as p43, is a component of the multi-aminoacyl-tRNA synthetase complex and also functions as a cytokine.{56094} Intracellular AIMP1 interacts with and stabilizes arginyl-tRNA synthetase, as well as negatively regulates TGF-? signaling by binding to and stabilizing Smurf2.{56095} AIMP1 can also be secreted from cells in response to stimuli including hypoxia, heat shock, and TNF-?, and secreted AIMP1 has a variety of roles in the regulation of angiogenesis, fibroblast proliferation, and glucose homeostasis.{56094,56096,56097} It also has pro-inflammatory activity and activates monocytes/macrophages, leading to the secretion of TNF-?, IL-8, and chemokine (C-C motif) ligand 2 (CCL2).{56097} Peripheral blood and synovial fluid levels of AIMP1 are elevated in patients with rheumatoid arthritis compared with peripheral blood isolated from healthy patients, and administration of the chimeric AIMP1 neutralizing antibody atliximab attenuates disease severity in a mouse model of collagen-induced arthritis.{56097} Intravenous administration of recombinant AIMP1 reduces tumor growth in an MKN45 stomach cancer mouse xenograft model.{56096} Cayman’s AIMP1 (human, recombinant) protein consists of 318 amino acids and has a calculated molecular weight of 35 kDa.
Territorial Availability: Available through Bertin Technologies only in France
| Size | 1 mg, 100 µg |
|---|---|
| Shipping | dry ice |
| Molecular weight | |
| Custom code | 3504.00 |
| Formulation | Lyophilized from sterile PBS, pH 7.4 |
| Purity | ≥95% estimated by SDS-PAGE |
| UNSPSC code | 12352204 |
Cayman Chemical’s mission is to help make research possible by supplying scientists worldwide with the basic research tools necessary for advancing human and animal health. Our utmost commitment to healthcare researchers is to offer the highest quality products with an affordable pricing policy.
Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.
Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.
Our organic and analytical chemists specialize in the rapid development of manufacturing processes and analytical methods to carry out clinical and commercial GMP-API production. Pre-clinical drug discovery efforts are currently underway in the areas of bone restoration and repair, muscular dystrophy, oncology, and inflammation. A separate group of Ph.D.-level scientists are dedicated to offering Hit-to-Lead Discovery and Profiling Services for epigenetic targets. Our knowledgeable chemists can be contracted to perform complete sample analysis for analytes measured by the majority of our assays. We also offer a wide range of analytical services using LC-MS/MS, HPLC, GC, and many other techniques.
Accreditations
ISO/IEC 17025:2005
ISO Guide 34:2009
Cayman is a leader in the field of emerging drugs of abuse, providing high-purity Schedule I-V Controlled Substances to federally-licensed laboratories and qualified academic research institutions for forensic analyses. We are certified by ACLASS Accreditation Services with dual accreditation to ISO/IEC 17025:2005 and ISO Guide 34:2009.
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To be used in conjunction with Cayman’s NAPE-PLD polyclonal antibody (aa 6-20) (Item No. 10306) to block protein-antibody complex formation...
