COX Inhibitor Pack
COX Inhibitor Pack
The Cayman COX Inhibitor Pack contains a combination of frequently used cyclooxygenase (COX) inhibitors. Each kit contains aspirin, the archetype...
€932.00
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From €85.00 €72.25
From €85.00 €72.25
CSB6B is a dye and derivative of glutamate with diverse biological activities.{59218,59219,59220,59221,59222} It is a competitive inhibitor of vesicular glutamate transporters (vGLUTs), inhibiting glutamate uptake by rat brain synaptic vesicles (Ki = 0.19 µM) but not by synaptosomes when used at a concentration of 0.1 mM.{59218} CSB6B is also an inhibitor of calcium/calmodulin-dependent protein kinase phosphatase (CaMKP) and its nuclear isoform CaMKP-N (IC50s = 4.1 and 1 µM, respectively).{59219} It is selective for CaMKP and CaMKP-N over protein phosphatase 2C (PP2C) and calcineurin, which it inhibits by less than 10 and 20%, respectively, at 10 µM. CSB6B inhibits sodium/taurocholate cotransporting polypeptide (NTCP; IC50 = 7.1 µM) and reduces hepatitis B virus (HBV) and hepatitis delta virus (HDV) infection in HepaRG cells when used at a concentration of 17 µM.{59220} Intracerebroventricular administration of CSB6B (0.5 µg) inhibits inflammatory pain in mice, reducing writhing induced by acetic acid and nociceptive behavior during the second phase of the formalin test without affecting locomotor activity.{59221} It also reduces thermal hyperalgesia in the complete Freund’s adjuvant test but not thermal pain in the hot plate test. CSB6B has also been used as a counterstain to reduce background autofluorescence in immunohistochemical preparations.{59222}
Territorial Availability: Available through Bertin Technologies only in France
| Size | 100 ?g, 25 g, 250 g, 50 g |
|---|---|
| Shipping | dry ice |
| CAS number | 01/05/2610 00:00 |
| Molecular formula | C34H24N6O16S4 • 4Na |
| Smiles | COC1=CC(C2=CC=C(C(OC)=C2)/N=N/C(C=CC3=C(S([O-])(=O)=O)C=C4S([O-])(=O)=O)=C(O)C3=C4N)=CC=C1/N=N/C(C=CC5=C(S([O-])(=O)=O)C=C6S([O-])(=O)=O)=C(C5=C6N)O.[Na+].[Na+].[Na+].[Na+] |
| Molecular weight | 992,8 |
| Custom code | 2930.90 |
| Formulation | A crystalline solid |
| Purity | ≥90% |
| UNSPSC code | 12352100 |
Cayman Chemical’s mission is to help make research possible by supplying scientists worldwide with the basic research tools necessary for advancing human and animal health. Our utmost commitment to healthcare researchers is to offer the highest quality products with an affordable pricing policy.
Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.
Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.
Our organic and analytical chemists specialize in the rapid development of manufacturing processes and analytical methods to carry out clinical and commercial GMP-API production. Pre-clinical drug discovery efforts are currently underway in the areas of bone restoration and repair, muscular dystrophy, oncology, and inflammation. A separate group of Ph.D.-level scientists are dedicated to offering Hit-to-Lead Discovery and Profiling Services for epigenetic targets. Our knowledgeable chemists can be contracted to perform complete sample analysis for analytes measured by the majority of our assays. We also offer a wide range of analytical services using LC-MS/MS, HPLC, GC, and many other techniques.
Accreditations
ISO/IEC 17025:2005
ISO Guide 34:2009
Cayman is a leader in the field of emerging drugs of abuse, providing high-purity Schedule I-V Controlled Substances to federally-licensed laboratories and qualified academic research institutions for forensic analyses. We are certified by ACLASS Accreditation Services with dual accreditation to ISO/IEC 17025:2005 and ISO Guide 34:2009.
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