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Demethylzeylasteral is a nortriterpenoid originally isolated from T. wilfordii that has diverse biological activities, including enzyme inhibitory, anti-angiogenic, antiproliferative, anti-inflammatory, and immunosuppressive properties.{45479,45480,45481,45482} Demethylzeylasteral inhibits the UDP-glucuronosyltransferase (UGT) isoforms UGT1A6 and UGT2B7 (Kis = 0.6 and 17.3 ?M, respectively).{45480} It inhibits growth of bovine aortic endothelial cells (BAEs) and U251 human glioma cancer cells in vitro (IC50s = 0.21 and ~6.2 ?M, respectively), as well as inhibits tumor growth and neovascularization in vivo in a B16/F10 melanoma mouse allograft model when administered at a dose of 30 mg/kg per day.{45479} Demethylzeylasteral (0.12 mg/kg per day) decreases renal proteinuria, lesions, immune cell infiltration, and protein levels of TNF-?, COX-2, and ICAM-1 in lupus-prone MRL/lpr mice.{45481} Demethylzeylasteral (10 mg/kg per day) also increases survival of recipient rats in a model of kidney transplant.{45482}
Territorial Availability: Available through Bertin Technologies only in France
| Size | 1 mg, 10 mg, 5 mg |
|---|---|
| Shipping | dry ice |
| CAS number | 107316-88-1 |
| Molecular formula | C29H36O6 |
| Smiles | O=CC1=C(C(C=C2[C@@]3(C)CC[C@]4(C)[C@]2(C)CC[C@]5(C)[C@@]4([H])C[C@@](C(O)=O)(C)CC5)=O)C3=CC(O)=C1O |
| Molecular weight | 480,6 |
| Custom code | 2937.29 |
| Formulation | A crystalline solid |
| Purity | ≥98% |
| UNSPSC code | 12352100 |
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Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.
Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.
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