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Telotristat etiprate is a prodrug form of telotristat, which is an inhibitor of tryptophan hydroxylase 1 (TPH1).{43269} Telotristat etiprate (15-300 mg/kg) reduces levels of serotonin (5-HT; Item No. 14332) in mouse jejunum and blood but not brain.{43270} It inhibits increases in IL-1? and IL-6 levels, histological damage in the colon, and weight loss in a mouse model of trinitrobenzene sulfonic acid-induced colitis when administered at a dose of 200 mg/kg. In mice infected with the nematode T. muris, telotristat etiprate (300 mg/kg per day) reduces colonic levels of myeloperoxidase (MPO), IL-1?, and IL-17, as well as worm burden.{43271} Formulations containing telotristat etiprate have been used in the treatment of diarrhea associated with carcinoid syndrome.
Territorial Availability: Available through Bertin Technologies only in France
| Size | 10 mg, 25 mg, 5 mg, 50 mg |
|---|---|
| Shipping | dry ice |
| CAS number | 1137608-69-5 |
| Molecular formula | C27H26ClF3N6O3 • C9H9NO3 |
| Smiles | NC1=NC(O[C@@H](C(F)(F)F)C2=CC=C(Cl)C=C2N3N=C(C)C=C3)=CC(C4=CC=C(C[C@H](N)C(OCC)=O)C=C4)=N1.O=C(NCC(O)=O)C5=CC=CC=C5 |
| Molecular weight | 754,2 |
| Custom code | 2933.59 |
| Formulation | A crystalline solid |
| Purity | ≥98% |
| UNSPSC code | 12352100 |
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Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.
Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.
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