From €48.00 €40.80
Hederacoside C is a saponin that has been found in K. pictus and has anti-inflammatory activity.{36806,36808} It is an inhibitor of acetylcholinesterase (AChE; IC50 = 31.3 ?M).{36808} Hederacoside C (0.5-5 ?g) inhibits mutagenicity induced by aflatoxin B1 (Item No. 11293) in S. typhimurium agar cultures from 21 to 67%.{36807} It reduces TNF-?, IL-1?, IL-6, COX-2, and nitric oxide synthase (NOS) levels in a concentration-dependent manner and IL-1 receptor-associated kinase-1 (IRAK1) activity in isolated mouse peritoneal macrophages stimulated by LPS when used at concentrations ranging from 5 to 10 ?M.{36806} Hederacoside C (0.02 mg/kg) reduces carrageenan-induced hind paw edema by 37% compared to vehicle control in a rat model of acute inflammation.{36809} It reduces scopolamine-induced memory impairment and increases latency in a passive avoidance test and spontaneous alteration in a Y-maze in mice by 100 and 59%, respectively, when administered at a dose of 40 mg/kg.{36808} Hederacoside C (5 mg/kg, i.p.) reduces serum levels of TNF-? and IL-1? in LPS-challenged mice by 60 and 65%, respectively.{36806}
Territorial Availability: Available through Bertin Technologies only in France
| Size | 10 mg, 100 mg, 25 mg, 50 mg |
|---|---|
| Shipping | dry ice |
| CAS number | 14216-03-6 |
| Molecular formula | C59H96O26 |
| Smiles | CC1(C)CC[C@]2(C(O[C@@H]3O[C@H](CO[C@H]4[C@H](O)[C@@H](O)[C@H](O[C@@]5([H])[C@H](O)[C@H](O)[C@@H](O)[C@H](C)O5)[C@@H](CO)O4)[C@@H](O)[C@H](O)[C@H]3O)=O)CC[C@@]6(C)[C@]7(C)CC[C@@]8([H])[C@@](CO)(C)[C@@H](O[C@]9([H])OC[C@H](O)[C@H](O)[C@H]9O[C@@]([H])[C@H](O)[C@H](O)[C@@H](O)[C@H](C)O)CC[C@]8(C)[C@@]7([H])CC=C6[C@]2([H])C1 |
| Molecular weight | 1221,4 |
| Custom code | 2932.99 |
| Formulation | A crystalline solid |
| Purity | ≥98% |
| UNSPSC code | 12352100 |
Cayman Chemical’s mission is to help make research possible by supplying scientists worldwide with the basic research tools necessary for advancing human and animal health. Our utmost commitment to healthcare researchers is to offer the highest quality products with an affordable pricing policy.
Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.
Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.
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