Herboxidiene is a polyketide originally isolated from S. chromofuscus that has diverse biological activities.{40942,40944,46191,46192,46193} It inhibits growth of HeLa S3, SK-MEL-2, PC3, A549, and EBC-1 cells with GI50 values ranging from 7.4 to 62 nM.{46191} Herboxidiene is cytostatic against human umbilical vein endothelial cells (HUVECs; (IC50 = 26 nM)) and inhibits VEGF-induced invasion and tube formation of serum-starved HUVECs in a concentration-dependent manner, indicating antiangiogenic activity.{46192} Herboxidiene (0.05 ?M) inhibits HIF-1? mRNA splicing and reduces HIF-1? protein levels in HepG2 cells grown under hypoxic conditions. It also inhibits splicing of p27Kip mRNA in HeLa cells in a concentration-dependent manner via interaction with the SAP155 subunit of the SF3b complex.{40944} Herboxidiene (0.1 and 1 ?M) increases LDL receptor promoter-driven transcription in a cell-based reporter assay.{46193} It also exhibits herbicidal activity against wild buckwheat, morning glory, maize, hemp sesbania, and rapeseed when applied at 0.069 kg/hectare.{40942}
Territorial Availability: Available through Bertin Technologies only in France
| Size | 1 mg, 500 µg |
|---|---|
| Shipping | dry ice |
| CAS number | 142861-00-5 |
| Molecular formula | C25H42O6 |
| Smiles | O=C(O)C[C@@H]1O[C@H](/C(C)=C/C=C/[C@@H](C)C[C@@]2(C)O[C@]2([H])[C@H](C)[C@@H](OC)[C@H](O)C)[C@@H](C)CC1 |
| Molecular weight | 438,6 |
| Custom code | 2910.90 |
| Formulation | A solid |
| Purity | ≥70% |
| UNSPSC code | 12352100 |
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