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Sanguinarine is a benzylisoquinoline alkaloid isolated from plants belonging to the family Papaveraceae.{22467} It exhibits antimicrobial, anti-inflammatory, and anti-oxidant properties and demonstrates antiproliferative and pro-apoptotic effects in some cancer cell lines. Sanguinarine suppresses NF-?B activation by blocking the degradation of I?B? and sensitizes cancer cells to apoptosis by inducing ROS generation and activating TNF-related apoptosis-inducing ligand.{25057} Furthermore, sanguinarine has been shown to reduce cancer cell metastasis though the inhibition of MMP-2 and MMP-9 activation and to exhibit antiangiogenic activity by downregulating VEGF-induced Akt activation.{25057}
Territorial Availability: Available through Bertin Technologies only in France
| Size | 1 mg, 10 mg, 25 mg, 5 mg |
|---|---|
| Shipping | dry ice |
| CAS number | 5578-73-4 |
| Molecular formula | C20H14NO4 • Cl |
| Smiles | C[N+]1=CC2=C(C=CC3=C2OCO3)C4=C1C5=CC(OCO6)=C6C=C5C=C4.[Cl-] |
| Molecular weight | 367,8 |
| Custom code | 2922.19 |
| Formulation | A crystalline solid |
| Purity | ≥98% |
| UNSPSC code | 12352100 |
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Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.
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