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20-ethyl Prostaglandin F2? (20-ethyl PGF2?) is an analog of PGF2? in which the ?-chain has been extended by the addition of two more methylene carbon atoms. It is therefore a modified version of the clinically approved glaucoma medication unoprostone.{8147} Unoprostone also contains lower side chain modifications (13,14-dihydro-15-keto) which severely limit its affinity for FP receptors, contributing to its lack of potency as a medication. 20-ethyl PGF2? retains the natural 15(S) allylic hydroxyl in the lower side chain, which may improve its potency as an intraocular hypotensive agent compared to unoprostone. The 2 carbon extension in 20-ethyl-PGF2? increases the Ki (120 nM) for the FP receptor from bovine corpus luteum only about 2.5-fold compared to PGF2? (50 nM).{11182} In vivo effects may be prolonged using 20-ethyl PGF2?, as the activity of 15-hydroxy PGDH using 20-ethyl PGF2? as a substrate is only 35% of the activity observed with PGF2?.{2309,11182}
Territorial Availability: Available through Bertin Technologies only in France
| Size | 1 mg, 10 mg, 5 mg |
|---|---|
| Shipping | dry ice |
| CAS number | 36950-85-3 |
| Molecular formula | C22H38O5 |
| Smiles | O[C@@H]1C[C@H](O)[C@H](C/C=CCCCC(O)=O)[C@H]1/C=C/[C@@H](O)CCCCCCC, O[C@@H]1C[C@H](O)[C@H](C/C=CCCCC(O)=O)[C@H]1/C=C/[C@@H](O)CCCCCCC, O[C@@H]1C[C@H](O)[C@H](C/C=CCCCC(O)=O)[C@H]1/C=C/[C@@H](O)CCCCCCC |
| Molecular weight | 382,5 |
| Custom code | 2937.50 |
| Formulation | A solution in methyl acetate |
| Purity | ≥98% |
| UNSPSC code | 12352100 |
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