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Unoprostone isopropyl ester (Rescula) is the clinically approved, prodrug form of unoprostone, which is a free acid analog of prostaglandin F2? (PGF2?). Both latanoprost and Rescula have been approved for the treatment of ocular hypertension. Both analogs of PGF2? are believed to act by increasing the rate of aqueous humor outflow through the uveoscleral pathway.{3586} Both drugs are believed to act as prodrugs, with endogenous esterases within the eye releasing the free acid active form of the drug. The typical does of Rescula (one drop of 0.12% solution) is nearly 100 times that of latanoprost.{8147} Rescula has very little activity on isolated DP or TP receptors, less than 0.0005% the activity of PGE2 on EP3 receptors, and about 3% of the activity of PGF2? on FP receptors.{8148}
Territorial Availability: Available through Bertin Technologies only in France
| Size | 1 mg, 10 mg, 5 mg, 50 mg |
|---|---|
| Shipping | dry ice |
| CAS number | 120373-24-2 |
| Molecular formula | C25H44O5 |
| Smiles | O[C@@H]1[C@H](C/C=CCCCC(OC(C)C)=O)[C@@H](CCC(CCCCCCC)=O)[C@H](O)C1, O[C@@H]1[C@H](C/C=CCCCC(OC(C)C)=O)[C@@H](CCC(CCCCCCC)=O)[C@H](O)C1, O[C@@H]1[C@H](C/C=CCCCC(OC(C)C)=O)[C@@H](CCC(CCCCCCC)=O)[C@H](O)C1, O[C@@H]1[C@H](C/C=CCCCC(OC(C)C)=O)[C@@H](CCC(CCCCCCC)=O)[C@H](O)C1 |
| Molecular weight | 424,6 |
| Custom code | 2937.50 |
| Formulation | A solution in methyl acetate |
| Purity | ≥95% |
| UNSPSC code | 12352100 |
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Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.
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