Territorial Availability: Available through Bertin Technologies only in France
- Correlated keywords
- WB western blots blotting IHC immunohistochemistry immunoblots proliferating cells nuclear antigens ipo38 flow cytometry immunocytochemistry ICC mitosis DNA polymerases holoenzymes antibodies antisera antiserum cancers immunoblotting FC
- Product Overview:
The proliferating cell nuclear antigen (PCNA) becomes detectable in the G1 phase of the cell cycle and reaches a maximum level of expression during mitosis. PCNA is highly conserved across species and is a critical part of the DNA polymerase ? holoenzyme.{12084,12085,12086} The level of PCNA expression depends on the proliferative potential of the cell examined. Caymanl’s PCNA Monoclonal Antibody can be used for analysis of PCNA by Western blot, flow cytometry, immunocytochemistry, and immunohistochemistry (frozen and paraffin-embedded tissue) on samples from multiple species. This monoclonal antibody stains proliferating cells in a wide range of normal tissues, as well as in tissues undergoing pathological processes and after mitogenic and allogeneic stimulations.
Cayman Chemical’s mission is to help make research possible by supplying scientists worldwide with the basic research tools necessary for advancing human and animal health. Our utmost commitment to healthcare researchers is to offer the highest quality products with an affordable pricing policy.
Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.
Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.
Our organic and analytical chemists specialize in the rapid development of manufacturing processes and analytical methods to carry out clinical and commercial GMP-API production. Pre-clinical drug discovery efforts are currently underway in the areas of bone restoration and repair, muscular dystrophy, oncology, and inflammation. A separate group of Ph.D.-level scientists are dedicated to offering Hit-to-Lead Discovery and Profiling Services for epigenetic targets. Our knowledgeable chemists can be contracted to perform complete sample analysis for analytes measured by the majority of our assays. We also offer a wide range of analytical services using LC-MS/MS, HPLC, GC, and many other techniques.
Accreditations
ISO/IEC 17025:2005
ISO Guide 34:2009
Cayman is a leader in the field of emerging drugs of abuse, providing high-purity Schedule I-V Controlled Substances to federally-licensed laboratories and qualified academic research institutions for forensic analyses. We are certified by ACLASS Accreditation Services with dual accreditation to ISO/IEC 17025:2005 and ISO Guide 34:2009.