Salvinorin B Mesylate
Salvinorin B Mesylate
Salvinorin B mesylate (Mesyl Sal B) is a selective ?-opioid receptor agonist that is more potent than salvinorin A (Item...
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From €59.00 €50.15
From €59.00 €50.15
Salvinorin B is the major deacetylated metabolite of salvinorin A (Item No. 11487).{36003,34652} It reportedly lacks pharmacological activity in vitro and in vivo when used in unperturbed systems. It binds as an agonist at the κ-opioid receptor (Ki = 2,950 nM; EC50 = 248 nM) but does not elicit antinociceptive effects even after i.c.v. administration. However, salvinorin B is a ligand for the inhibitory G protein-coupled κ-opioid designer receptor exclusively activated by designer drugs (DREADD; KORD; EC50s = 11.8 and 160 nM with high or low levels of KORD expression, respectively).{38358} It leads to hyperpolarization and inhibition of neuronal firing in neurons expressing KORD and has no effect on neurons transduced with mCherry as a control. Salvinorin B increases locomotor activity in VGAT-ires-Cre mice expressing KORD in the ventral tegmental area and substantia nigra, increases food intake in SIM1-Cre mice expressing KORD in the paraventricular hypothalamus, and decreases food intake in AGRP-ires-Cre mice expressing KORD in the arcuate nucleus. Salvinorin B can be used in combination with clozapine N-oxide (CNO; Item No. 16882) because it is inactive at Gq-based DREADDs. Salvinorin B is also available as an analytical reference standard (Item No. 11488).
Territorial Availability: Available through Bertin Technologies only in France
| Size | 1 mg, 10 mg, 25 mg, 5 mg |
|---|---|
| Shipping | dry ice |
| CAS Number | 92545-30-7 |
| Molecular Formula | C21H26O7 |
| SMILES | O=C1[C@]2([H])CC[C@@]([C@@]3([H])[C@@]2(C)C[C@@H](C4=COC=C4)O1)(C)[C@H](C(OC)=O)C[C@H](O)C3=O |
| Molecular Weight | 390,4 |
| Formulation | A crystalline solid |
| Purity | ≥95% |
| Custom Code | 2932.19 |
| UNSPSC code | 12352100 |
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