€615.00 €522.75
Paired box (Pax) protein 8 (Pax8) is a transcription factor and member of the Pax family that functions as both a transcriptional activator and repressor and has an essential role in thyroid development.{15190,64179} It is composed of a DNA-binding paired domain, conserved octapeptide, partial homeodomain, transactivation domain, and an inhibitory domain.{15190,64180} Alternative splicing of PAX8 pre-mRNA encoding the C-terminus results in five isoforms with varying DNA-binding capabilities and transcriptional activities.{64181} Pax8 is expressed during the mesenchymal-to-epithelial transition in the development of various organs and localizes to the nucleus. It is involved in cell survival, differentiation, and stem cell lineage commitment.{15190} Knockout of Pax8 produces smaller thyroids without follicles in mice.{64182} PAX8 mutations have been found in patients with thyroid dysgenesis, and chromosomal translocations leading to the fusion of PAX8 with PPARG, resulting in expression of Pax8-PPAR? fusion proteins, are associated with follicular thyroid carcinomas.{64179,8382} Cayman’s Pax8 (C-Term) Rabbit Monoclonal Antibody can be used for immunohistochemistry (IHC).
Territorial Availability: Available through Bertin Technologies only in France
| Size | 100 µl |
|---|---|
| Shipping | dry ice |
| Molecular weight | 0 |
| Host | Rabbit |
| Antigen | A peptide from the C-terminal region of human Pax8 |
| Clone | RM436 |
| Isotype | IgG |
| Application(s) | IHC |
| Formulation | 100 µl of protein A-affinity purified monoclonal antibody |
| Custom code | 3822.19 |
| UNSPSC code | 12352203 |
Cayman Chemical’s mission is to help make research possible by supplying scientists worldwide with the basic research tools necessary for advancing human and animal health. Our utmost commitment to healthcare researchers is to offer the highest quality products with an affordable pricing policy.
Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.
Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.
Our organic and analytical chemists specialize in the rapid development of manufacturing processes and analytical methods to carry out clinical and commercial GMP-API production. Pre-clinical drug discovery efforts are currently underway in the areas of bone restoration and repair, muscular dystrophy, oncology, and inflammation. A separate group of Ph.D.-level scientists are dedicated to offering Hit-to-Lead Discovery and Profiling Services for epigenetic targets. Our knowledgeable chemists can be contracted to perform complete sample analysis for analytes measured by the majority of our assays. We also offer a wide range of analytical services using LC-MS/MS, HPLC, GC, and many other techniques.
Accreditations
ISO/IEC 17025:2005
ISO Guide 34:2009
Cayman is a leader in the field of emerging drugs of abuse, providing high-purity Schedule I-V Controlled Substances to federally-licensed laboratories and qualified academic research institutions for forensic analyses. We are certified by ACLASS Accreditation Services with dual accreditation to ISO/IEC 17025:2005 and ISO Guide 34:2009.
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